A. We define the Grothendieck group of an n-exangulated category. For n odd, we show that this group shares many properties with the Grothendieck group of an exact or a triangulated category. In particular, we classify dense complete subcategories of n-exangulated categories with an n-(co)generator in terms of subgroups of the Grothendieck group. This unifies and extends results of Thomason, Bergh-Thaule, Matsui and Zhu-Zhuang for triangulated, (n+2)-angulated, exact and extriangulated categories, respectively.