From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited

Rihn, Bertrand; Saliou, Claude; Bottin, M.C.; Keith, Gérard; Packer, Lester

doi:10.1002/1099-1573(200102)15:1<76::aid-ptr747>3.0.co;2-o

Cited by 17 publications

(12 citation statements)

References 5 publications

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“…Bito et al (73) reported that 12 hour pretreatment with Pycnogenol significantly inhibited in a dose-dependent manner IFN-γ induced expression of ICAM-1 in the human immortalized keratinocytes cell line HaCAT. This observations pairs with the reported modulatory effects of Pycnogenol on the adhesion of Jurkat T cells to activated keratinocytes in a cocultutre assay (74). Using gel mobility shift assay, it was identified STAT-1 and IRF-1 as two transcription factors affected by Pycnogenol, critical for IFN-γ dependent gene activation (74).…”

Section: Nutrigenomicssupporting

confidence: 74%

The nutraceutical Pycnogenol: its role in cardiovascular health and blood glucose control

Gulati

2005

Biomedical Reviews

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Pycnogenol ® (a registered trademark of Horphag Research Ltd.) is French maritime pine bark extract of the outer bark of Pinus pinaster Ait. Subsp. atlantica. Its specifications are described in the USP 28-Dietary supplements. Pycnogenol has strong antioxidant profile proven by in vitro and in vivo studies and further confirmed in clinical trials. Its strong antioxidant profile, vasodilator activity, antithrombotic effect and collagen stabilizing property make it a unique health product. In humans, Pycnogenol has been shown to lower blood pressure in mild to moderate hypertensive individuals and blood glucose levels in diabetics. In this review the diverse biological effects of Pycnogenol are presented and discussed using a target-oriented approach, in health and disease conditions like edema, inflammation, chronic venous insufficiency, deep vein thrombosis, diabetes, diabetic retinopathy, and hypertension. The future trends are the continuous efforts proving its efficacy in conditions which involves oxidative stress and inflammation. Recent preliminary study utilizing "high throughput" methodology and nutrigenomics approach are able to provide a new insight into the molecular mechanism of the biological activity of this botanical sourced nutraceutical.

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Section: Nutrigenomicssupporting

confidence: 74%

The nutraceutical Pycnogenol: its role in cardiovascular health and blood glucose control

Gulati

2005

Biomedical Reviews

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“…Pycnogenol 1 with its potent ability to scavenge free radicals ( Blazso et al, 1994;Virgili et al, 1998) may act by blocking these effects of free radicals or may have some other mechanism of action to inhibit cell function and histamine release from mast cells. In this context it is noteworthy that Pycnogenol 1 has an inhibitory effect on a number of intracellular metabolic processes including the expression of adhesion molecule-1 (ICAM-1) (Bito et al, 2000), Calrgranulin A/B gene expression ( Rihn et al, 2001) and the activation of nuclear factor NF-kappa b . Pycnogenol 1 has even been shown to reduce blood pressure (Blazso et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Pycnogenol® inhibits the release of histamine from mast cells

Sharma

Gulati

2003

Phytotherapy Research

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Oxygen derived free radicals are now increasingly regarded as a primary force of tissue destruction and also have the ability to release histamine from mast cells. Pycnogenol is an extract of the bark of French maritime pine (Pinus pinaster) containing bioflavonoids with a potent ability to scavenge free radicals. Therefore Pycnogenol was investigated for inhibition of histamine release from rat peritoneal mast cells. In addition, its effects were compared with sodium cromoglycate, a known inhibitor of histamine release from the mast cell. Rat peritoneal mast cells were isolated and purified by differential centrifugation and cells pooled from 3-4 animals were suspended at approximately 10(6) cells/mL buffered salt solution. Histamine release was induced by compound 48/80 or the calcium ionophore A-23187 and estimated from supernatant following extraction and by fluorimetric methods. Pycnogenol produced a concentration dependent inhibition of histamine release induced by the two secretagogues. Its inhibitory effect on mast cell histamine release was favourably comparable to sodium cromoglycate.

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“…bark extract (PBE), a mixture particularly rich in polyphenolic compounds, has been suggested as potentially useful for the treatment of psoriasis. PBE has shown to downregulate calgranulin A and B genes in HaCaT keratinocytes (Rihn et al, 2001) and to inhibit interferon-gamma induced adhesion of T cells to keratinocytes by inhibiting inducible inter-cellular adhesion molecule 1 (Bito et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, toxicological and antiproliferative properties of Canadian polyphenolic extracts on normal and psoriatic keratinocytes

García-Pérez

Royer

Duque-Fernandez

et al. 2010

Journal of Ethnopharmacology

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From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited

Cited by 17 publications

References 5 publications

The nutraceutical Pycnogenol: its role in cardiovascular health and blood glucose control

The nutraceutical Pycnogenol: its role in cardiovascular health and blood glucose control

Pycnogenol® inhibits the release of histamine from mast cells

Antioxidant, toxicological and antiproliferative properties of Canadian polyphenolic extracts on normal and psoriatic keratinocytes

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