From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC‐KUS in 71 children with vitiligo

Schallreuter, Karin U.; Krüger, Christian; Würfel, Brigitte A.; Panske, Angela; Wood, John M.

doi:10.1111/j.1365-4632.2008.03660.x

Cited by 88 publications

(70 citation statements)

References 39 publications

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Section: Hydrogen Peroxide Accumulation and Antioxidative Enzyme Deplmentioning

confidence: 99%

“…A UVB-activated pseudocatalase, a bis-manganese III-EDTA-(HCO3-)2 complex, was suggested for the removal of hydrogen peroxide in vitiligo therapy and was shown to induce repigmentation in several studies [64,[67][68][69]. One pseudocatalase study of 71 children with vitiligo showed good but variable degree of repigmentation on the face, neck, trunk and extremities, but almost no repigmentation on hands and feet, suggesting the need for more mechanistic studies on the possible therapeutic effect of the catalase approach [68]. Unfortunately, other vitiligo studies using pseudocatalase with narrow band-UVB activation did not show added benefit to the UVB exposure alone [70,71], further supporting the need to identify the vitiligo subpopulation that might benefit from the pseudocatalase treatment.…”

Section: Hydrogen Peroxide Accumulation and Antioxidative Enzyme Deplmentioning

confidence: 99%

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Age‐induced hair greying – the multiple effects of oxidative stress

Seiberg¹

2013

Intern J of Cosmetic Sci

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SynopsisAn obvious sign of ageing is hair greying, or the loss of pigment production and deposition within the hair shafts. Numerous mechanisms, acting at different levels and follicular locations, contribute to hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death. One key issue that is in common to these processes is oxidative damage. At the hair follicle stem cells niche, oxidative stress, accelerated by B-cell lymphoma 2 gene (BCL-2) depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles. Melanotic bulbar melanocytes express high levels of BCL-2 to enable survival from melanogenesis-and ultraviolet A (UVA)-induced reactive oxygen species (ROS) attacks. With ageing, the bulbar melanocyte expression of anti-oxidant proteins such as BCL-2, and possibly TRP-2, is reduced, and the dedicated enzymatic anti-oxidant defence system throughout the follicle weakens, resulting in enhanced oxidative stress. A marked reduction in catalase expression and activity results in millimolar accumulation of hydrogen peroxide, contributing to bulbar melanocyte malfunction and death. Interestingly, amelanotic melanocytes at the outer root sheath (ORS) are somewhat less affected by these processes and survive for longer time even within the white, ageing hair follicles. Better understanding of the overtime susceptibility of melanocytes to oxidative stress at the different follicular locations might yield clues to possible therapies for the prevention and reversal of hair greying.R esum e Un signe evident du vieillissement est le grisonnement des cheveux ou la perte de la production de pigment et de son d epôt dans les follicules pileux. De nombreux m ecanismes, agissant a diff erents niveaux et endroits folliculaires, contribuent aux cheveux grisonnants, allant des dommages aux cellules souches m elanocytaires a la mort des m elanocytes folliculaires. Une question cl e qui est commune a ces processus concerne le dommage oxydatif. Au niveau de la niche des cellules souches du follicule, le stress oxydatif, acc el er e par l'appauvrissement de BCL-2, conduit a l'apoptose et a une diminution s elective des cellules souches des m elanocytes, ce qui r eduit le repeuplement des follicules anag enes nouvellement form es. Les m elanocytes bulbaires m elaniques expriment des niveaux elev es de Bcl-2 pour permettre la survie suite a l'attaque par les esp eces r eactives de l'oxyg ene (ROS) induites par la m elanog en ese et les ultraviolets A (UVA). Avec le vieillissement, l'expression dans m elanocytes du bulbe des prot eines anti-oxydantes comme BCL-2, et peut-être TRP-2, est r eduite, et la d efense sp ecifique du syst eme antioxydant enzymatique faiblit a travers le follicule, r esultant en un plus grand stress oxydatif. Une r eduction marqu ee de l'expression catalase et les r esultats de l'activit e de l'accumulation millimolaire de peroxyde d'hydrog ene contribuent a un dysfonctionnement et a la mort des m elanocytes b...

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Section: Hydrogen Peroxide Accumulation and Antioxidative Enzyme Deplmentioning

confidence: 99%

Section: Hydrogen Peroxide Accumulation and Antioxidative Enzyme Deplmentioning

confidence: 99%

Age‐induced hair greying – the multiple effects of oxidative stress

Seiberg¹

2013

Intern J of Cosmetic Sci

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“…Vitiligoda oksidatif stresin etiyolojide rol oynayabileceğinin gösterilmesiyle gündeme gelen bu tedavide psödokatalaz epidermal H2O2'yi elimine etmektedir. Bu kombine tedavinin pediatrik vitiligo olgularında 8-12 ay uygulanmasıyla yüz ve boyun lezyonlarında 71 hastanın 66'sında, gövde lezyonlarında 61 hastanın 48'inde ve ekstremite lezyonlarında 55 hastanın 40'ında %75'ten fazla repigmentasyon elde edildiği bildirilmiştir 29 .…”

Section: Psödokatalazunclassified

Childhood Vitiligo

Köse¹,

Özmen²

2011

Turkderm

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“…Angenommen werden zum einen 7 autozytotoxische Prozesse, bei denen oxidativer Stress als das Resultat einer Anhäufung von Wasserstoffperoxid und einer Verminderung von Katalase, einem wichtigen Radikalfänger der Zellen, pathogenetisch bedeutsam scheint [21]. Zum anderen werden 7 Autoimmunmechanismen favorisiert, gestützt durch die Assoziation mit anderen Autoimmunerkrankungen, dem Nachweis antimelanozytärer Antikörper und läsionaler lymphozytärer Entzündungsinfiltrate [19,15].…”

Section: Pathogeneseunclassified

“…Nach europäischem Konsens werden die klinischen Erscheinungsformen der Vitiligo unterteilt in F einen nicht-segmentalen (symmetrischen) Typ ("non-segmental vitiligo"/NSV) und F einen segmentalen (asymmetrischen) Typ ("segmental vitiligo"/SV; [23] [21]. Aktive Vitiligoareale zeigen an den sich vergrö-ßernden Abschnitten eine nach außen gerichtete (konvexe) Begrenzung und gelegentlich einen entzündlichen Aspekt mit begleitendem Juckreiz.…”

Section: Klinikunclassified

Vitiligo

Hartmann

2009

Hautarzt

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Vitiligo is characterized by patches of depigmented skin in a localized to generalized distribution. Up to now, vitiligo is not curable and mostly has a chronic and progressive course. The disorder may be part of a polygenic, multifactorial transmitted disease with an increased disposition to autoimmune disorders, which should be screened for. Depending on the age of the patient, the psychological strain, the location, the body surface area involved, and the disease activity, several conservative as well as surgical therapeutic options may be partially successful. How long the induced repigmentation remains and the effect of the available therapeutic options on the natural history of vitiligo remain to be clarified.

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From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC‐KUS in 71 children with vitiligo

Abstract: A reduction in epidermal H(2)O(2) using low-dose, narrow-band UV-B-activated pseudocatalase PC-KUS is an effective treatment for childhood vitiligo which can be safely performed at home.

Cited by 88 publications

References 39 publications

Age‐induced hair greying – the multiple effects of oxidative stress

Age‐induced hair greying – the multiple effects of oxidative stress

Childhood Vitiligo

Vitiligo

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