From bench to clinic: Emerging therapies for corneal scarring

Corneal Wound Healing in the Presence of Antifibrotic Antibody Targeting Collagen Fibrillogenesis: A Pilot Study

“…Clinically applied methods to reduce corneal scarring include topical anti-inflammatory steroids, which affect numerous processes associated with scar formation [32]. Moreover, antiproliferative mitomycin C and 5-fluorouracil are also used to minimize corneal scarring [13]. Based on the synchronous correlation assay, in the Un cornea region, the depthdependent changes in the collagen-specific and PG-specific FTIR-derived signals co-occurred in the same direction.…”

“…Clinically applied methods to reduce corneal scarring include topical anti-inflammatory steroids, which affect numerous processes associated with scar formation [32]. Moreover, antiproliferative mitomycin C and 5-fluorouracil are also used to minimize corneal scarring [13].…”

“…Consequently, scientists have developed and tested novel experimental methods to reduce corneal scarring [13]. For instance, gene therapy techniques with viral-vector-based gene delivery were proposed to target profibrotic TGFβ1-dependent pathways [11,13].…”

“…Consequently, scientists have developed and tested novel experimental methods to reduce corneal scarring [13]. For instance, gene therapy techniques with viral-vector-based gene delivery were proposed to target profibrotic TGFβ1-dependent pathways [11,13]. Moreover, researchers have considered repurposing some drugs approved for other disorders and applying them to limit corneal scarring.…”

“…Therefore, preventing excessive scar formation is a rational approach to reducing the risk of unwanted consequences of corneal injuries. Although numerous methods have been tested to achieve this goal, no adequate antiscarring agents have been developed thus far [12,13].…”