2020
DOI: 10.15255/cabeq.2020.1783
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From Bio-waste to Bone Substitute

Abstract: Nanocomposite structure of the bone can be mimicked by chitosan/hydroxyapatite (CS/HAp) composite scaffold. Biological hydroxyapatite (HAp) contains various ions, which have a crucial role in bone growth. The aim of the present work was to synthesize biomimetic hydroxyapatite and prepare composite scaffolds based on chitosan, where HAp was synthesised from hen eggshells, seashells and cuttlefish bone. The powders were composed of nano-structured calcium deficient HAp and amorphous calcium phosphate (ACP). In t… Show more

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Cited by 22 publications
(19 citation statements)
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“…Utku et al successfully prepared fibroin/hydroxyapatite scaffolds by dissolving fibroin and hydroxyapatite in phosphate buffer [2]. Ressler et al learned from research that the nanocomposite structure of bone can be simulated by chitosan/hydroxyapatite (CS/HAp) composite scaffold [3]. Vurat et al developed a novel osteogenic composite nanocoating for titanium surfaces.…”
Section: Related Workmentioning
confidence: 99%
See 1 more Smart Citation
“…Utku et al successfully prepared fibroin/hydroxyapatite scaffolds by dissolving fibroin and hydroxyapatite in phosphate buffer [2]. Ressler et al learned from research that the nanocomposite structure of bone can be simulated by chitosan/hydroxyapatite (CS/HAp) composite scaffold [3]. Vurat et al developed a novel osteogenic composite nanocoating for titanium surfaces.…”
Section: Related Workmentioning
confidence: 99%
“…It acts as a temporary extracellular matrix, providing a favorable microenvironment for growth, thereby promoting cell differentiation. (3) Finally, it simulates the parallel arrangement of tendon collagen fibers to prepare parallel ordered nano-parallel material composite proteins. is can induce the directional differentiation of fibroblasts to the tendon system, so as to achieve the effect of repairing the nerve tendon.…”
Section: Introductionmentioning
confidence: 99%
“…Scaffolds porosity was measured following the Archimedes method as previously described by Ressler et al [22], by immersing each scaffold in ethanol (ρ = 0.789 g cm -3 ) at room temperature. The porosity (%) was then calculated from the fraction of the volume of the pores (V pore ) within the total volume of the scaffold (V CS/HA ) based on Eq.…”
Section: Characterization Methodsmentioning
confidence: 99%
“…However, the trace elements detected in the phosphate ore used in this work can play a key role to obtain a multi-substituted HA that mimic the inorganic phase of human bone. They can improve its biological performance as they can increase proliferation and differentiation of osteoblast cells, and decrease osteoclast cells activity [22]. [31].…”
Section: Characterization Of Np Orementioning
confidence: 99%
“…HA is a compound that has a hexagonal structure with white solids [19]. Because it has biocompatibility, bioactivity [20][21][22] and significant osteoinductivity [23], hydroxyapatite has been widely used as a bone substitute to fill bone defects, such as matrix scaffolding for tissue engineering [24] and as a coating on biomedical implants [20]. In biomedical applications, biomaterials must have reliable biocompatibility capabilities [25].…”
Section: Introductionmentioning
confidence: 99%