From cerebral palsy to developmental coordination disorder: Development of preclinical rat models corresponding to recent epidemiological changes

Coq, Jacques‐Olivier; Kochmann, Marine; Lacerda, Diego Cabral; Khalki, Hanane; Delcour, Maxime; Toscano, Ana Elisa; Cayetanot, Florence; Canu, Marie‐Hélène; Barbe, Mary F.; Tsuji, Masahiro

doi:10.1016/j.rehab.2019.10.002

Cited by 20 publications

(17 citation statements)

References 68 publications

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“…Figure 2 represents the architecture of the implemented U-Net. It receives as input patches of dimension 32 3 and produces two segmentation maps of dimension 32 3 corresponding to the two classes (background and brain) after applying a Softmax function. All convolution operations are done with padding.…”

Section: U-net Network Architecturementioning

confidence: 99%

“…Animal models [2] are needed to better understand in vivo mechanism of early brain lesion and neuroplasticity as they offer controlled experimental conditions. Whereas CP rodent model exists [3], compare to human, these latter may have potential bias and differences and omit important context, possibly hampering reliable translational outcomes. Thus, other animal models are required [2].…”

Section: Introductionmentioning

confidence: 99%

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Patch-based 3D U-Net and transfer learning for longitudinal piglet brain segmentation on MRI

Coupeau

Fasquel

Mazerand

et al. 2022

Computer Methods and Programs in Biomedicine

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Section: U-net Network Architecturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Patch-based 3D U-Net and transfer learning for longitudinal piglet brain segmentation on MRI

Coupeau

Fasquel

Mazerand

et al. 2022

Computer Methods and Programs in Biomedicine

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“…Motor skill training or rehabilitation is commonly associated with improvements in balance and walking ability of the lower limbs ( 10 ). In contrast, the quantity and quality of training are essential to promote plasticity and functional recovery of the child's brain ( 11 ). Therefore, developing a practical intensive training or rehabilitation program requires consideration of time and intensity ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Virtual Reality on Balance Function in Children With Cerebral Palsy: A Systematic Review and Meta-analysis

Liu

Hu²,

et al. 2022

Front. Public Health

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Virtual Reality (VR) therapy is popular in treating children with Cerebral Palsy (CP) as a new technology for rehabilitation. Nevertheless, no substantial evidence supporting VR therapy promotion has been developed to date. This study aimed to investigate the effects of VR therapy on balance in children with CP. We conducted a systematic search in PubMed and Web of Science (updated to December 30, 2021). The systematic review and meta-analysis included all randomized controlled trials that included children with CP. A total of 18 RCT studies were eligible for inclusion in the systematic review, and meta-analysis was performed on 16 of them. Results showed that the VR intervention was beneficial for balance (SMD 0.47 [95% CI, SD 0.28, 0.66]). We concluded that VR therapy interventions for children with CP have positive effects. However, cautious implementation is needed in clinical applications.

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“…Why this is not the case in this study might be explained by the different rearing conditions and "exercise" in these studies, where in Vanden Hole et al (23,24) the piglets were vaginally delivered, did not receive artificial feeding, and remained with the sow in a farm environment. The postnatal environment also proved its importance in rat pups, which suffer from abnormal locomotion that lasted even until adulthood when rats were subjected to both prenatal (i.e., intrauterine hypoperfusion) and postnatal (i.e., sensorimotor restriction) insults (36). Studies on gait symmetry (and stability) in human preterms are inconclusive on whether or not a difference exists and whether this is maintained throughout development (6).…”

Section: Discussion the Effect Of Premature Birthmentioning

confidence: 99%

Preterm Birth Affects Early Motor Development in Pigs

et al. 2021

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Background: Preterm infants frequently show neuromotor dysfunctions, but it is not clear how reduced gestational age at birth may induce developmental coordination disorders. Advancing postnatal age, not only post-conceptional age, may determine neuromuscular development, and early interventions in preterm newborns may improve their later motor skills. An animal model of preterm birth that allows early postnatal detection of movement patterns may help to investigate this hypothesis.Methods: Using pigs as a model for moderately preterm infants, preterm (106-day gestation, equivalent to 90% of normal gestation time; n = 38) and term (115-day gestation, equivalent to 99% of normal gestation time; n = 20) individuals were delivered by cesarean section and artificially reared until postnatal day 19 (preweaning period). The neuromotor skills of piglets were documented using spatiotemporal gait analyses on video recordings of locomotion at self-selected speed at postnatal age 3, 4, 5, 8, and 18 days. Results were controlled for effects of body weight and sex.Results: Both preterm and term piglets reached mature neuromotor skills and performance between postnatal days 3–5. However, preterm pigs took shorter steps at a higher frequency, than term piglets, irrespective of their body size. Within preterm pigs, males and low birth weight individuals took the shortest steps, and with the highest frequency.Conclusion: Postnatal development of motor skills and gait characteristics in pigs delivered in late gestation may show similarity to the compromised development of gait pattern in preterm infants. Relative to term pigs, the postnatal delay in gait development in preterm pigs was only few days, that is, much shorter than the 10-day reduction in gestation length. This indicates rapid postnatal adaptation of gait pattern after reduced gestational age at birth. Early-life physical training and medical interventions may support both short- and long-term gait development after preterm birth in both pigs and infants.

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From cerebral palsy to developmental coordination disorder: Development of preclinical rat models corresponding to recent epidemiological changes

Abstract: The most common physical disability in children, cerebral palsy 22 (CP), involves a group of disorder of movement and posture and of 23 motor function, including spasticity (85-91% of cases) and is 24 caused by a lesion, interference or abnormality that originates in

Cited by 20 publications

References 68 publications

Patch-based 3D U-Net and transfer learning for longitudinal piglet brain segmentation on MRI

Patch-based 3D U-Net and transfer learning for longitudinal piglet brain segmentation on MRI

Effect of Virtual Reality on Balance Function in Children With Cerebral Palsy: A Systematic Review and Meta-analysis

Preterm Birth Affects Early Motor Development in Pigs

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