The fundamental objective of earthquake engineering is to protect lives and livelihoods through the reduction of seismic risk. Directly or indirectly, this generally requires quantification of the risk, for which quantification of the seismic hazard is required as a basic input. Over the last several decades, the practice of seismic hazard analysis has evolved enormously, firstly with the introduction of a rational framework for handling the apparent randomness in earthquake processes, which also enabled risk assessments to consider both the severity and likelihood of earthquake effects. The next major evolutionary step was the identification of epistemic uncertainties related to incomplete knowledge, and the formulation of frameworks for both their quantification and their incorporation into hazard assessments. Despite these advances in the practice of seismic hazard analysis, it is not uncommon for the acceptance of seismic hazard estimates to be hindered by invalid comparisons, resistance to new information that challenges prevailing views, and attachment to previous estimates of the hazard. The challenge of achieving impartial acceptance of seismic hazard and risk estimates becomes even more acute in the case of earthquakes attributed to human activities. A more rational evaluation of seismic hazard and risk due to induced earthquakes may be facilitated by adopting, with appropriate adaptations, the advances in risk quantification and risk mitigation developed for natural seismicity. While such practices may provide an impartial starting point for decision making regarding risk mitigation measures, the most promising avenue to achieve broad societal acceptance of the risks associated with induced earthquakes is through effective regulation, which needs to be transparent, independent, and informed by risk considerations based on both sound seismological science and reliable earthquake engineering.