From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction

Simon, Lisa; Admon, Roee

doi:10.1038/s41386-023-01638-9

Cited by 20 publications

(5 citation statements)

References 267 publications

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“… 24 High sensory stress is common in gynecologic cancer patients, which leads to disturbance of sleep physiological process, change of sleep structure, and then sleep disorders. 50 …”

Section: Discussionmentioning

confidence: 99%

“…49 Long-term stress level is associated with hyperactivity of the hypothalamic-pituitary-adrenal pathway, shortened sleep time, and reduced deep sleep, leading to poor sleep quality, impaired memory, and poor emotional regulation, which in turn lead to more stress. 50 Therefore, the greater the stress, the more likely it is to experience sleep disorders. The Mediating Effect of Perceived Stress Between Self-Stigma and Sleep Disorders…”

Section: Profiles Of Sleep Disorders and Associated Factorsmentioning

confidence: 99%

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Study on the Profiles of Sleep Disorders, Associated Factors, and Pathways Among Gynecological Cancer Patients – A Latent Profile Analysis

Gu,

Wang,

Yang

et al. 2024

NSS

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Background: Gynecological cancer generally refers to malignant tumors in gynecology, commonly including cervical cancer, endometrial cancer, and ovarian cancer. Patients with gynecological cancer often suffer from sleep disorders after clinical treatment. Except for serious sleep disorders, female characteristics, family roles, and feudal beliefs make their self-stigma at a medium to high level, leading to huge pressure. This study aims to identify potential categories of sleep disorders, and analyze the relationship between self-stigma, perceived stress, and sleep disorders. Methods: A cross-sectional study was conducted in 2021-2022. Two hundred and two patients' data were collected from ShengJing Hospital Affiliated to China Medical University in Liaoning, Shenyang by using paper questionnaires for face-to-face surveys. The survey tools included the Pittsburgh Sleep Quality Index (PSQI), the Perceived Stress Scale (PSS), and the Social Impact Scale (SIS). Potential profile analysis (LPA), multiple logistic regression analysis, and structural equation modeling (SEM) were performed by Mplus 8.3, SPSS 26.0, and Amos 24.0 statistical tools, respectively. Results: Three latent patterns of sleep disorders were found: "Good Sleep group (42.5%)", "Sleep Deficiency group (32.4%)", and "Sleep Disturbance group (25.1%)". Patients with high perceived stress were more likely to report a moderate (OR=1.142, 95% CI: 1.061-1.230) or high (OR=1.455, 95% CI: 1.291-1.640) level of sleep disorders. Self-stigma did not have a direct effect on sleep disorders (0.055, P>0.05), but it could have indirect effect on sleep disorders through perceived stress (0.172, P<0.01). Conclusion:The perceptions of sleep disorders among gynecological cancer patients varies and exhibits individual differences. Gynecological cancer patients who feels alienated or discriminated may cause high pressure. This internal pressure can exacerbate sleep disorders.

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“… 24 High sensory stress is common in gynecologic cancer patients, which leads to disturbance of sleep physiological process, change of sleep structure, and then sleep disorders. 50 …”

Section: Discussionmentioning

confidence: 99%

Section: Profiles Of Sleep Disorders and Associated Factorsmentioning

confidence: 99%

Study on the Profiles of Sleep Disorders, Associated Factors, and Pathways Among Gynecological Cancer Patients – A Latent Profile Analysis

Gu,

Wang,

Yang

et al. 2024

NSS

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“…Research indicates that childhood maltreatment can lead to a complex interplay between the hypothalamic-pituitary-adrenal (HPA) axis and sleep regulation mechanisms. This dynamic interaction often results in a bidirectional relationship where sleep disturbances and HPA axis dysfunction mutually exacerbate each other, 22 leading to higher suicidal risk. 23 , 24 Finally, previous empirical studies have already found that insomnia could mediate the relationship between childhood maltreatment and suicide ideation in adolescents with depression 25 and the non-clinical population.…”

Section: Insomnia As a Potential Mediator Between Childhood Maltreatm...mentioning

confidence: 99%

Association between childhood maltreatment and suicidal ideation among Chinese patients with chronic schizophrenia: the mediating role of insomnia

Hao,

Peng,

Wang

et al. 2024

BJPsych open

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Background Childhood maltreatment is a well-established transdiagnostic risk factor for suicidal ideation; however, previous studies on their association in schizophrenia have produced highly varied results. Moreover, the mechanism linking childhood maltreatment and suicide ideation remains unclear in schizophrenia. Aims This cross-sectional study aimed to investigate the association between childhood maltreatment and suicide ideation in people with schizophrenia and tested whether insomnia mediated this relationship. Method Positive and Negative Syndrome Scale (PANSS), Insomnia Severity Index (ISI), Childhood Trauma Questionnaire – Short Form and Beck Suicidal Ideation Inventory were employed. Logistic regression and mediation analysis were performed. Results (a) The prevalence of suicide ideation, insomnia, sexual abuse, emotional neglect, emotional abuse, physical abuse and physical neglect was 10% (n = 61), 18% (n = 111), 11% (n = 68), 25% (n = 153), 6.3% (n = 39), 17% (n = 106) and 39% (n = 239), respectively. In all, 52% (n = 320) reported childhood maltreatment; (b) patients with suicide ideation demonstrated higher insomnia and childhood maltreatment. PANSS depression factor, ISI, lifetime suicidal attempts and emotional abuse were independently associated with suicide ideation; (c) insomnia partially mediated the effects of emotional abuse and emotional neglect on suicide ideation, and insomnia completely mediated the effects of physical neglect and physical abuse on suicide ideation. Conclusion Our study calls for formal assessments for childhood maltreatment and insomnia in schizophrenia, which might help identify suicide ideation early. In addition, interventions targeting insomnia might help reduce suicide ideation among people with schizophrenia who experience childhood maltreatment.

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“…Cortisol typically follows a diurnal pattern, peaking in the morning and tapering off at night. However, dysregulated HPA axis activity can disrupt this rhythm, leading to untimely surges in cortisol levels, particularly during the evening and nighttime hours [ 50 , 51 , 52 ].…”

Section: The Neurobiology Of Sleepmentioning

confidence: 99%

Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders

Camberos-Barraza,

Camacho-Zamora,

Bátiz-Beltrán

et al. 2024

IJMS

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The relationship between sleep, glial cells, and the endocannabinoid system represents a multifaceted regulatory network with profound implications for neuroinflammation and cognitive function. The molecular underpinnings of sleep modulation by the endocannabinoid system and its influence on glial cell activity are discussed, shedding light on the reciprocal relationships that govern these processes. Emphasis is placed on understanding the role of glial cells in mediating neuroinflammatory responses and their modulation by sleep patterns. Additionally, this review examines how the endocannabinoid system interfaces with glia-immune signaling to regulate inflammatory cascades within the central nervous system. Notably, the cognitive consequences of disrupted sleep, neuroinflammation, and glial dysfunction are addressed, encompassing implications for neurodegenerative disorders, mood disturbances, and cognitive decline. Insights into the bidirectional modulation of cognitive function by the endocannabinoid system in the context of sleep and glial activity are explored, providing a comprehensive perspective on the potential mechanisms underlying cognitive impairments associated with sleep disturbances. Furthermore, this review examines potential therapeutic avenues targeting the endocannabinoid system to mitigate neuroinflammation, restore glial homeostasis, and normalize sleep patterns. The identification of novel therapeutic targets within this intricate regulatory network holds promise for addressing conditions characterized by disrupted sleep, neuroinflammation, and cognitive dysfunction. This work aims to examine the complexities of neural regulation and identify potential avenues for therapeutic intervention.

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From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction

Cited by 20 publications

References 267 publications

Study on the Profiles of Sleep Disorders, Associated Factors, and Pathways Among Gynecological Cancer Patients – A Latent Profile Analysis

Study on the Profiles of Sleep Disorders, Associated Factors, and Pathways Among Gynecological Cancer Patients – A Latent Profile Analysis

Association between childhood maltreatment and suicidal ideation among Chinese patients with chronic schizophrenia: the mediating role of insomnia

Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders

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