From clock to functional pacemaker

Michel, Stephan; Meijer, Johanna H.

doi:10.1111/ejn.14388

Cited by 43 publications

(45 citation statements)

References 117 publications

(133 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, the properties that turn a community of individual cell oscillators into a coherent and reliable circadian pacemaker originate from the SCN itself [56,57]. The comparison of individual SCN neuron electrical rhythmicity in dispersed cell cultures and within SCN slices revealed that circadian precision increases significantly when the native tissue context is preserved.…”

Section: The Origin Of Circadian Precision and Robustness Within Tmentioning

confidence: 99%

Molecular and Cellular Networks in The Suprachiasmatic Nuclei

Hussein

Mollard

Bonnefont

2019

IJMS

View full text Add to dashboard Cite

Why do we experience the ailments of jetlag when we travel across time zones? Why is working night-shifts so detrimental to our health? In other words, why can’t we readily choose and stick to non-24 h rhythms? Actually, our daily behavior and physiology do not simply result from the passive reaction of our organism to the external cycle of days and nights. Instead, an internal clock drives the variations in our bodily functions with a period close to 24 h, which is supposed to enhance fitness to regular and predictable changes of our natural environment. This so-called circadian clock relies on a molecular mechanism that generates rhythmicity in virtually all of our cells. However, the robustness of the circadian clock and its resilience to phase shifts emerge from the interaction between cell-autonomous oscillators within the suprachiasmatic nuclei (SCN) of the hypothalamus. Thus, managing jetlag and other circadian disorders will undoubtedly require extensive knowledge of the functional organization of SCN cell networks. Here, we review the molecular and cellular principles of circadian timekeeping, and their integration in the multi-cellular complexity of the SCN. We propose that new, in vivo imaging techniques now enable to address these questions directly in freely moving animals.

show abstract

Section: The Origin Of Circadian Precision and Robustness Within Tmentioning

confidence: 99%

Molecular and Cellular Networks in The Suprachiasmatic Nuclei

Hussein

Mollard

Bonnefont

2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Pacemaker cells function individually as autonomous single-cell oscillators and together, as an ensemble, in a highly synchronized way as a multioscillator system. Multioscillator systems in the suprachiasmatic nucleus control circadian rhythms in the brain and other individual organs (Michel and Meijer 2020). The oscillation at the single pacemaker cell level is based on a negative feedback loop wherein the level of clock gene expression is determined by the amount of the corresponding protein product accumulated within the cell (Buhr and Takahashi 2013).…”

Section: Pacemaker Cellsmentioning

confidence: 99%

“…If single-cell oscillations of pacemaker cells in the suprachiasmatic nucleus run uncoordinated or in different phases, the multioscillator system is desynchronized, and, in consequence, the brain and other organs function with different circadian rhythms. Thus, a unified circadian rhythm across the organism requires sufficient synchronization among pacemaker cells (Michel and Meijer 2020).…”

Section: Pacemaker Cellsmentioning

confidence: 99%

Channels to consciousness: a possible role of gap junctions in consciousness

Dere

Zlomuzica²,

Dere

2020

Reviews in the Neurosciences

View full text Add to dashboard Cite

The neurophysiological basis of consciousness is still unknown and one of the most challenging questions in the field of neuroscience and related disciplines. We propose that consciousness is characterized by the maintenance of mental representations of internal and external stimuli for the execution of cognitive operations. Consciousness cannot exist without working memory, and it is likely that consciousness and working memory share the same neural substrates. Here, we present a novel psychological and neurophysiological framework that explains the role of consciousness for cognition, adaptive behavior, and everyday life. A hypothetical architecture of consciousness is presented that is organized as a system of operation and storage units named platforms that are controlled by a consciousness center (central executive/online platform). Platforms maintain mental representations or contents, are entrusted with different executive functions, and operate at different levels of consciousness. The model includes conscious-mode central executive/online and mental time travel platforms and semiconscious steady-state and preconscious standby platforms. Mental representations or contents are represented by neural circuits and their support cells (astrocytes, oligodendrocytes, etc.) and become conscious when neural circuits reverberate, that is, fire sequentially and continuously with relative synchronicity. Reverberatory activity in neural circuits may be initiated and maintained by pacemaker cells/neural circuit pulsars, enhanced electronic coupling via gap junctions, and unapposed hemichannel opening. The central executive/online platform controls which mental representations or contents should become conscious by recruiting pacemaker cells/neural network pulsars, the opening of hemichannels, and promoting enhanced neural circuit coupling via gap junctions.

show abstract

“…The authors point out that the fruit fly is a classic model that can be used to study the interactions between the circadian clock and age‐related decline because of the short life span and the neurogenetic tools that are available (De Nobrega & Lyons, ). In mammals, ageing impacts SCN‐regulated pathways, including sleep timing and entrainment to the LD cycle (Michel & Meijer, ). Specifically, electrical and neurochemical rhythms that are dampened in the aged SCN are due, at least in part, to an increase in firing of an anti‐phased SCN neuronal subpopulation.…”

Section: Evolution and Adaptation Of Clocksmentioning

confidence: 99%

Circadian rhythmicity and the community of clockworkers

Gamble

Silver

2019

Eur J of Neuroscience

View full text Add to dashboard Cite

ReviewCauston, Helen C. Metab olic rhyth ms: A frame work for coord inati ng cellu lar function Golden, Susan S. Princ iples of rhyth micit y emerg ing from cyano bacteria Loros, Jennifer J. Princ iples of the anima l molec ular clock learn ed from Neuro spora Circadian rhythms in complex systems Exp't Gillette, Martha U. Circa dian rhyth m of redox state regul ates membr ane excit abili ty in hippo campa l CA1 neurons Prosser, Rebecca A. Coppe r in the supra chias matic circa dian clock : A possi ble link betwe en multi ple circa dian oscil lators Silver, Rae Overe xpres sion of stria tal D2 recep tors reduc es motiv ation there by decre asing food antic ipato ry activity Stengl, Monika Circa dian pacem aker neuro ns of the Madei ra cockr oach are inhib ited and activ ated by GABAA and GABAB recep tors Review Evans, Jennifer A. Circu it devel opmen t in the maste r clock netwo rk of mammals Gamble, Karen L. Circa dian regul ation of membr ane physi ology in neura l oscil lator s throu ghout the brain Green, Carla B. Perio dicit y, repre ssion , and the molec ular archi tectu re of the mamma lian circa dian clock Helfrich-Föerster, Charlotte Flies as model s for circa dian clock adapt ation to envir onmen tal chall enges Honma, Sato Devel opmen t of the mamma lian circa dian clock Ko, Gladys Y.-P. Circa dian regul ation in the retin a: From molec ules to network Mahoney, Megan M. Modul ation of circa dian rhyth ms throu gh estro gen recep tor signa ling Maywood, Elizabeth S. Synch roniz ation and maint enanc e of circa dian timin g in the mamma lian clock work Mongrain, Valérie Trans cript ional contr ol of synap tic compo nents by the clock machi nery Sehgal, Amita Molec ular and circu it mecha nisms media ting circa dian clock outpu t in the Droso phila brain Sumová, Alena Myste ry of rhyth mic signa l emerg ence withi n the supra chias matic nuclei Clocks in health and disruption Exp't Harrington, Mary E. Recur ring circa dian disru ption alter s circa dian clock sensi tivit y to reset ting Martha Merrow Strat egies to decre ase socia l jetla g: Reduc ing eveni ng blue light advan ces sleep and melat onin Skene, Debra J. Effec t of acute total sleep depri vatio n on plasm a melat onin, corti sol and metab olite rhyth ms in females Review Boivin, Diane B. Metab olic and cardi ovasc ular conse quenc es of shift work: The role of circa dian disru ption and sleep distu rbances Cirelli, Chiara Sleep and synap tic down-selec tion Duncan, Marilyn J. Inter actin g influ ences of aging and Alzhe imer's disea se on circa dian rhythms Fu, Ying-Hui The molec ular genet ics of human sleep González-Mariscal, Gabriela Behav ioral , neuro endoc rine and physi ologi cal indic ators of the circa dian biolo gy of male and femal e rabbits Lyons, Lisa C. Aging and the clock : Persp ectiv e from flies to humans McClung, Colleen A. Mood-relat ed centr al and perip heral clocks Meijer, Johanna H. From clock to funct ional pacem aker Shirasu-Hiza, Mimi Tired and stres sed: Exami ning the need for sleep Simonneaux, Valérie A Kiss to dr...

show abstract

From clock to functional pacemaker

Cited by 43 publications

References 117 publications

Molecular and Cellular Networks in The Suprachiasmatic Nuclei

Molecular and Cellular Networks in The Suprachiasmatic Nuclei

Channels to consciousness: a possible role of gap junctions in consciousness

Circadian rhythmicity and the community of clockworkers

Contact Info

Product

Resources

About