From coronavirus disease 2019 to long coronavirus disease 2019 in vascular pathology

Farinetti, Alberto; Manenti, Antonio; Manco, Gianrocco; Roncati, Luca; Coppi, Francesca; Mattioli, Anna Vittoria

doi:10.1016/j.jvs.2022.03.897

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Long COVID (defined as occurring 12 weeks after the original infection) is characterized by symptoms lasting for many months in subjects who have had a severe, moderate, or mild form of COVID-19. 1-4…”

Section: Introductionmentioning

confidence: 99%

Vascular “Long COVID”: A New Vessel Disease?

et al. 2023

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Vascular sequelae following (SARS-CoV-2 coronavirus disease) (COVID)-19 infection are considered as “Long Covid (LC)” disease, when occurring 12 weeks after the original infection. The paucity of specific data can be obviated by translating pathophysiological elements from the original Severe Acute Respiratory Syndrome-Corona Virus (SARS-CoV-2) infection (In a microcirculatory system, a first “endotheliitis,” is often followed by production of “Neutrophil Extracellular Trap,” and can evolve into a more complex leukocytoklastic-like and hyperimmune vasculitis. In medium/large-sized vessels, this corresponds to endothelial dysfunction, leading to an accelerated progression of pre-existing atherosclerotic plaques through an increased deposition of platelets, circulating inflammatory cells and proteins. Associated dysregulated immune and pro-coagulant conditions can directly cause thrombo-embolic arterial or venous complications. In order to implement appropriate treatment, physicians need to consider vascular pathologies observed after SARS-Cov-2 infections as possible “LC” disease.

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Section: Introductionmentioning

confidence: 99%