Here I consider two women writers whose work marks a transition from the Baroque to Enlightenment. Margaret Cavendish figures in two diverging intellectual worlds. There are multiple rich, if often contradictory, Baroque aspects to her life and writings. However, she later developed an ambivalence towards the new empirical science, the dynamics of which point us beyond the Baroque to the Enlightenment. Aphra Behn’s groundbreaking writings are frequently described as Baroque but she, too, is moving into a new cultural paradigm: just as, at the beginning of the period, the Baroque spasmodically surfaced in Pembroke and Lanyer, in the late seventeenth century, some Baroque characteristics blazed spectacularly before merging into Enlightenment culture and literary neo-classicism.