From experiment to experience: Side effects of nonsteroidal anti-inflammatory drugs

Coles, L. Stephen; Fries, James F.; Kraines, R. Guy; Roth, Sanford H.

doi:10.1016/0002-9343(83)91073-2

Cited by 121 publications

(27 citation statements)

References 11 publications

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“…Cutaneous side effects of NSAID are rare having been reported in only 1%-3% of cases [2]. As many as 135 various skin reactions have been reported, varying from minor photosensitivity adverse effects such as erythema and urticaria to life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis.…”

Section: Discussionmentioning

confidence: 99%

Naproxen-Induced Leukocytoclastic Vasculitis

Schapira

Balbir‐Gurman

Nahir

2000

Clinical Rheumatology

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Cutaneous reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are rare in spite of their wide use. Only a few cases of hypersensitivity angiitis related to naproxen have been described. We report the case of a 62-year-old woman in whom leukocytoclastic skin vasculitis, peripheral neuropathy and nephritis developed after a short naproxen treatment, and gradually regressed after discontinuation of the drug and under glucocorticoid therapy. In the light of the relevant literature, the clinical and laboratory features of this reversible condition are described.

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Section: Discussionmentioning

confidence: 99%

Naproxen-Induced Leukocytoclastic Vasculitis

Schapira

Balbir‐Gurman

Nahir

2000

Clinical Rheumatology

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“…These drugs can reduce the signs and symptoms of axial involvement, however they do not alter the underlying mechanisms of the disease or prevent damage within the joint structure (Dougados et al, 1999). Between 10% and 60% of patients taking NSAIDs will have minor gastrointestinal symptoms such as nausea, indigestion and diarrhoea (Coles et al, 1983) The newer COX-2 selective NSAIDs are associated with a marked decrease in gastrointestinal side effects. However, recent studies in rheumatoid arthritis and osteoarthritis have determined that there may be a potential risk of cardiovascular events in some patients (Simon et al, 1999;Mukherjee, 2001).…”

Section: Medicationmentioning

confidence: 99%

Ankylosing spondylitis: clinical update

Cornell

Oliver

2004

Musculoskeletal Care

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“…Differences in the safety profiles of different NSAIDs have yet to be established (Carson et al, 1987;Caruso & Biandu Porro, 1980;Coles et al, 1983; Committee for the Safety of Medicines, 1986;Griffin et al, 1991;Paulus, 1985). There are many methodological difficulties including: the difficulty of establishing equipotent doses; self-selection of patients in non-randomised surveys; and bias in retrospective surveys.…”

Section: Non-steroidal Anti Inflammatory Drugsmentioning

confidence: 99%

The treatment of osteoarthritis.

Jones

Doherty

1992

Brit J Clinical Pharma

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1. The treatment of osteoarthritis is currently purely symptomatic. To enable rational therapy, careful clinical assessment is necessary to identify the origin of symptoms. Often, effective therapy can result from a biomechanical approach such as surgery, orthotics, physiotherapy and dieting. If drugs are required, there is little evidence that the current over‐reliance on non‐steroidal anti‐inflammatory drugs (NSAIDs) is justified. Full dose regular paracetamol should be the first line of analgesic therapy. In the majority of patients, simple analgesics are probably as effective as NSAIDs. If NSAIDs are used it is necessary to review regularly their use and to be aware of potential toxicity. 2. Many alternative strategies of pain management such as topical preparations, intra‐articular steroid injections, acupuncture, radiosynovectomy, transcutaneous nerve stimulation and anti‐ depressants, may be effective but their precise place in the armamentarium is not yet fully established. 3. The realisation that osteoarthritis is not a passive ‘wear and tear’ phenomenon but an active process that may be potentially modified, has led to interest in ‘chondroprotective’ agents, which may beneficially affect the osteoarthritic process. To date there are no convincing data available that such agents are, in fact, chondroprotective in humans.

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From experiment to experience: Side effects of nonsteroidal anti-inflammatory drugs

Cited by 121 publications

References 11 publications

Naproxen-Induced Leukocytoclastic Vasculitis

Naproxen-Induced Leukocytoclastic Vasculitis

Ankylosing spondylitis: clinical update

The treatment of osteoarthritis.

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