From Gastroprotective to Ulcerogenic Effects of Glucocorticoids: Role of Long-Term Glucocorticoid Action

Filaretova, Ludmila; Podvigina, T. T.; Bagaeva, T. R.; Morozova, Olga

doi:10.2174/13816128113199990419

Cited by 20 publications

(17 citation statements)

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“…); however, glucocorticoid therapy increases the risk of gastric ulceration in human patients and small animals (Boothe and Mealey ; Filaretova et al . ). More studies to identify the risk for the development of gastric ulcers in horses after high doses or prolonged therapies with glucocorticoids are warranted.…”

Section: Resultsmentioning

confidence: 97%

Review of glucocorticoid therapy in horses. Part 2: Clinical use of systemic glucocorticoids in horses

Pereira

Groover

Wooldridge

et al. 2016

Equine Veterinary Education

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Summary This article is the second in a review series about the use of glucocorticoids to treat medical and musculoskeletal conditions in horses. This segment in the series summarises reported dosages, methods of administration and the efficacy of glucocorticoids for various systemic diseases in equids. The most common use of systemic glucocorticoids reported in the literature for management and treatment of alterations of the respiratory, integumentary, immune and neurological systems are included.

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Section: Resultsmentioning

confidence: 97%

Review of glucocorticoid therapy in horses. Part 2: Clinical use of systemic glucocorticoids in horses

Pereira

Groover

Wooldridge

et al. 2016

Equine Veterinary Education

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“…The activation of hypothalamic-pituitary-adrenal (HPA) system under the conditions of stress-induced gastric lesion has been known leading to the elevated secretion of ACTH and corticosterone [45]. Such intensive increase of glucocorticoids in serum results in severe damage of gastric mucosa [46]. Hyperactivation of HPA system leads to the deep depletion of pituitary and adrenal glands activity and thereafter aggravation of ulcers [44].…”

Section: Discussionmentioning

confidence: 99%

Quercetin and Ellagic Acid in Gastric Ulcer Prevention: An Integrated Scheme of the Potential Mechanisms of Action From in Vivo Study

Kotob

Sayed

Mohamed

et al. 2018

Asian J Pharm Clin Res

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Objective: The present study was initiated to describe the gastroprotective role of quercetin (Qu) and ellagic acid (EA) on aspirin-induced gastric ulcer (GU) in rats.Methods: Forty adult female albino rats of Wistar strain were distributed into: Control group, GU group, Omeprazole group, Qu group, and EA group. Gross examination, biochemical analyses including serum adrenocorticotropic hormone (ACTH), serotonin (ST), ferritin, heme oxygenase-1 (HO-1), interleukin-2 (IL-2), advanced glycosylation end products (AGEs), and fibronectin (FN) levels were estimated. Moreover, histopathological and histochemical examinations of stomach tissue samples were carried out.Results: Gross examination of gastric mucosa of rats in GU group revealed hyperemia of the stomach mucosa. Furthermore, rats in GU group experienced a significant rise in serum ACTH, ferritin, HO-1, IL-2 and AGEs levels accompanied with significant drop in serum ST and FN levels versus control counterparts. Pre-treatment of GU group with Omeprazole, Qu or EA caused marked improvement in the measured biochemical parameters. Histopathological and histochemical examinations of stomach tissue samples documented the protective action of Omeprazole, Qu and EA with different degrees against GU caused by aspirin. Conclusion:As a conclusion to this study, we can state that both Qu and EA have gastroprotective effect against aspirin-induced GU in rat model. Of note, Qu showed superior impact than EA as an antiulcer agent in this study. The corresponding mechanisms are speculated to be associated with inhibiting stress-induced gastric lesion, attenuating the oxidative stress, iron chelation and blunting ferritin level, modulating inflammatory cascade, and promoting the healing process.

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“…To continue our strategy of using integrative approach ( Filaretova et al 2002;Filaretova et al 2006;Filaretova et al 2009;Filaretova 2011;Filaretova et al 2014) and to understand what happens with the body as a whole ("in vivo"), in the present study we evaluated somatic and behavior changes in rats treated with IM at gastric ulcerogenic dose. Additionally to an appearance of severe injury to the small intestine, body and thymus weights were reduced while adrenal weight and the morning plasma corticosterone levels were enhanced 3 days after IM injection (Fig.…”

Section: Discussionmentioning

confidence: 99%

A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose

Filaretova

Bagaeva

Morozova

et al. 2014

endo

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Objective. Gastric erosion is widespread side effect of nonsteroidal anti-inflammatory drugs. To examine the complexity of the brain-gut axis regulation, indomethacin-induced gastric erosion formation was studied in connection with somatic and behavioral changes.Methods. During a constant telemetric recording of heart rate, body temperature, and locomotion of male rats we examined the effects of 24 h fasting, indomethacin (35 mg/kg s.c.) injection, and refeeding at 4 h. Behavior was analyzed on elevated plus maze (EPM) at 24 h and somatic changes at 72 h.Results. Gastric erosion developed 4 h after indomethacin injection, healed 72 h later contrasted by large injury in the small intestine. As classical signs of chronic stress, body and thymus weight were reduced while adrenal weight was enhanced 72 h after indomethacin injection. Fasting by itself changed all telemetrically recorded parameters with most prominent decrease in heart rate. Indomethacin induced similar diminishing effects with earliest and strongest temperature decrease. As a sign of more anxious phenotype locomotion reducing effect of indomethacin injection was detected on EPM. The EPM-induced temperature elevation was missing in indomethacin-treated animals.Conclusions. Fasting by itself induce somatic changes, which can make the animals more vulnerable to ulcerogenic stimuli. Development of indomethacin-induced gastrointestinal lesions happened in parallel with disturbances of heart rate, core body temperature, and chronic stress-like somatic changes as well as anxiety-like behavior. We have to be more aware of the existence of the brain-gut axis and should study changes in the whole body rather than focusing on a specific organ.

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From Gastroprotective to Ulcerogenic Effects of Glucocorticoids: Role of Long-Term Glucocorticoid Action

Cited by 20 publications

References 0 publications

Review of glucocorticoid therapy in horses. Part 2: Clinical use of systemic glucocorticoids in horses

Review of glucocorticoid therapy in horses. Part 2: Clinical use of systemic glucocorticoids in horses

Quercetin and Ellagic Acid in Gastric Ulcer Prevention: An Integrated Scheme of the Potential Mechanisms of Action From in Vivo Study

A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose

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