From genes to chronotypes: the influence of circadian clock genes on our daily patterns of sleep and wakefulness

Verwey, Michael; Amir, Shimon

doi:10.21037/atm.2016.04.19

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Hypocretin As Regulator Of Waking State1

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Cited by 3 publications

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“…The waking state is controlled by several neurobiological networks, including circadian, homeostatic influences as well as by genetic, molecular, neuroanatomical and neurochemical elements [12][13][14]. For example, waking is modulated by the activity of diverse neurotransmitter systems such as noradrenaline, dopamine, serotonin, acetylcholine, histamine and hypocretin [3,[15][16][17][18][19][20][21][22][23][24] (Fig.…”

Section: Hypocretin As Regulator Of Waking Statementioning

confidence: 99%

Neurobiological Role of Hypocretin in Regulation of Psychiatric Disorders

Monteiro

Paes

et al. 2018

Sleep Vigilance

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Hypocretins are hypothalamic neuropeptides acting on the regulation of several physiological functions, the most important being the control of arousal. Hypocretin 1 and hypocretin 2 are derived from the same precursor and both bind to the orexin receptors. The hypocretinergic system has been a target of several studies that try to understand its function on the regulation of mood and behavior. The hypocretinergic system has a direct relationship with the pathways related to emotions and reward system, besides the interaction with the stress circuit. This article aims to analyze the relationship of hypocretins with anxiety, stress and depression, through a review of the existing literature.

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