From glow-sticks to sensors: single-electrode electrochemical detection for paper-based devices

Vidal, Ezequiel; Domini, Claudia E.; Whitehead, Daniel C.; Garcı́a, Carlos D.

doi:10.1039/d2sd00041e

Cited by 13 publications

(3 citation statements)

References 69 publications

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“…Paper-based analytical devices (μPADs) and their electroanalytical derivations (ePADs) play an important role as modern analytical tools and have been applied in several areas such as medicine, − forensics, , food science, , environmental analysis, and the pharmaceutical industry . When deployed as point-of-care (POC) sensors, these devices can provide appropriate sensitivity to detect not only metabolites but also pathogens such as SARS-CoV-2 virus, ebola virus, Escherichia coli (E.…”

Section: Introductionmentioning

confidence: 99%

Rapid Detection of Staphylococcus aureus Using Paper-Derived Electrochemical Biosensors

et al. 2022

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Several groups have recently explored the idea of developing electrochemical paper-based wearable devices, specifically targeting metabolites in sweat. While these sensors have the potential to provide a breadth of analytical information, there are several key challenges to address before these sensors can be widely adopted for clinical interventions. Toward this goal, we describe the development of a paper-based electrochemical sensor for the detection of Staphylococcus aureus. Enabling the application, this report describes the use of paper-derived carbon electrodes, which were modified with a thin layer of sputtered gold (that minimizes lateral resistivity and significantly improves the electron transfer process) and with chitosan (used as a binder, to offer flexibility). The resulting material was laser-patterned and applied for the development of an electrochemical biosensor controlled (via a wireless connection) by a custom-built, portable potentiostat. As no interference was observed when exposed to other bacteria or common metabolites, this wearable system (paper-derived electrodes + potentiostat) has the potential to detect the presence of S. aureus in the skin, a commonly misdiagnosed and mistreated infection.

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Section: Introductionmentioning

confidence: 99%

Rapid Detection of Staphylococcus aureus Using Paper-Derived Electrochemical Biosensors

et al. 2022

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“…S16 †). 57,58 To examine the sensitivity of BPPyz toward TNP, the Stern-Volmer (S-V) constant (K SV ) was calculated using the Stern-Volmer equation, I 0 /I = 1 + K SV [Q], where I 0 represents the initial fluorescence intensity in the absence of the analyte, I denotes the intensity in the presence of the analyte, [Q] is the molar concentration of the analyte and K SV is the quenching constant. The quenching constant (K SV ) for BPPyz was found to be 4.12 × 10 5 M −1 , confirming the high sensitivity of BPPyz toward TNP (Fig.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Detection of TNP and sulfite ions in an aqueous medium using a pyrazinium-based chemosensor

Pragya,

Rangan,

Khungar

2024

Sens. Diagn.

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“…Paper-based microfluidic devices represent a promising analytical platform that made great strides during the SARS-CoV-2 pandemic. [1][2][3] In addition to colorimetric approaches, these devices can be coupled with electrochemical (amperometric [4][5][6] or bipolar [7] ) detection, opening new possibilities for detecting biologically-active molecules. These electrochemical paperbased devices (ePADs) provide design versatility and enable the use of various substrates [8][9][10][11][12] for their fabrication.…”

Section: Introductionmentioning

confidence: 99%

Au‐Modified Carbon Electrodes Produced by Laser Scribing for Electrochemical Analysis of Probiotic Activity

Gongoni,

Chumanov,

Paixão

et al. 2023

Analysis & Sensing

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A simple and fast (<15 min), two‐step laser scribing of cardboard substrates is described as a method for fabricating carbon electrodes modified with metallic nanoparticles. The first scribing step patterned a cardboard substrate (promoting the formation of porous carbon electrodes). The second step was included to produce metallic nanoparticles via a chemical reduction process of cations from an aqueous solution. For these experiments, the effects of copper, silver, nickel, cobalt, zinc, and gold were evaluated considering their effect on the electrical properties and the composition of the carbon materials produced. These experiments revealed that, despite significant changes in resistance (from 138±7 Ω for plain electrodes to just 53±3 Ω for Au‐modified electrodes), only marginal changes were observed in the morphology or composition of the material produced (IG/ID ranged from 1.2±0.3 for the plain cardboard to 1.8±0.3 for the cobalt‐modified electrodes). To demonstrate the applicability of the proposed strategy, Au‐modified electrodes were assembled into electrochemical sensors and applied to measure the metabolic activity of live microorganisms in various commercial samples, requiring only 100 μL of sample and 10 min of incubation time.

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From glow-sticks to sensors: single-electrode electrochemical detection for paper-based devices

Abstract: With the goal of creating a multipurpose platform for electrogenerated luminescence, a single electrode electrochemical system was designed, developed, and validated. Glow sticks were used as the source of luminophore,...

Cited by 13 publications

References 69 publications

Rapid Detection of Staphylococcus aureus Using Paper-Derived Electrochemical Biosensors

Rapid Detection of Staphylococcus aureus Using Paper-Derived Electrochemical Biosensors

Detection of TNP and sulfite ions in an aqueous medium using a pyrazinium-based chemosensor

Au‐Modified Carbon Electrodes Produced by Laser Scribing for Electrochemical Analysis of Probiotic Activity

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