2020
DOI: 10.1242/dev.193888
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From head to tail: regionalization of the neural crest

Abstract: The neural crest is regionalized along the anteroposterior axis, as demonstrated by foundational lineage-tracing experiments that showed the restricted developmental potential of neural crest cells originating in the head. Here, we explore how recent studies of experimental embryology, genetic circuits and stem cell differentiation have shaped our understanding of the mechanisms that establish axial-specific populations of neural crest cells. Additionally, we evaluate how comparative, anatomical and genomic ap… Show more

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Cited by 28 publications
(18 citation statements)
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“…According to their position on the anteroposterior axis, migration behavior and differentiation potential, migrating NC cells are divided into cranial, vagal (including cardiac), trunk and sacral NC cells ( Yntema and Hammond, 1954 ; Le Douarin and Teillet, 1974 ; Noden, 1975 , 1978a ; reviewed by Rothstein et al, 2018 ). Cranial NC cells firstly undergo EMT and form a range of craniofacial cell types and tissues such as peripheral nerves, melanocytes, thyroid cells, teeth and most of the craniofacial skeleton ( Johnston, 1966 ; Noden, 1978a , b ; Baker et al, 1997 ; see reviews from Graham et al, 2004 ; Kaltschmidt et al, 2012 ; Rocha et al, 2020 for overview; Figure 3A ). Vagal NC cells give rise to enteric neurons and glia forming the enteric nervous system of the foregut and stomach, while an anterior localized subset, the cardiac NC cells, contributes to septation of the outflow tract in the developing heart ( Phillips et al, 1987 ; Burns and Douarin, 1998 ).…”
Section: Adult Neural Crest-derived Stem Cells—from Individual Developmental Drivers To Mediators Of Regeneration During Adulthoodmentioning
confidence: 99%
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“…According to their position on the anteroposterior axis, migration behavior and differentiation potential, migrating NC cells are divided into cranial, vagal (including cardiac), trunk and sacral NC cells ( Yntema and Hammond, 1954 ; Le Douarin and Teillet, 1974 ; Noden, 1975 , 1978a ; reviewed by Rothstein et al, 2018 ). Cranial NC cells firstly undergo EMT and form a range of craniofacial cell types and tissues such as peripheral nerves, melanocytes, thyroid cells, teeth and most of the craniofacial skeleton ( Johnston, 1966 ; Noden, 1978a , b ; Baker et al, 1997 ; see reviews from Graham et al, 2004 ; Kaltschmidt et al, 2012 ; Rocha et al, 2020 for overview; Figure 3A ). Vagal NC cells give rise to enteric neurons and glia forming the enteric nervous system of the foregut and stomach, while an anterior localized subset, the cardiac NC cells, contributes to septation of the outflow tract in the developing heart ( Phillips et al, 1987 ; Burns and Douarin, 1998 ).…”
Section: Adult Neural Crest-derived Stem Cells—from Individual Developmental Drivers To Mediators Of Regeneration During Adulthoodmentioning
confidence: 99%
“…This kind of lineage segregation also occurs in the development of different subpopulations deriving from neural crest stem cells, which give rise to a broad variety of ectodermal and mesenchymal cell types during embryogenesis ( Dupin and Sommer, 2012 ; Kaltschmidt et al, 2012 ; Etchevers et al, 2019 ). In accordance to their specific position on the anteroposterior axis, differentiation potential as well as migration behavior is coordinated resulting in cranial, vagal (including cardiac), trunk and sacral NC cells ( Rothstein et al, 2018 ; Rocha et al, 2020 ; see also section “Adult Neural Crest-Derived Stem Cells—From Individual Developmental Drivers to Mediators of Regeneration During Adulthood”). Such developmental-based heterogeneity results in tissue-specific gene expressions, which were recently investigated by Han and colleagues using scRNA-seq to determine the cell-type composition of all major human organs, leading to the construction of a scheme for the human cell landscape.…”
Section: Potential Origins Of Ncsc-heterogeneitymentioning
confidence: 99%
“…The cell type diversification of the sclerotome lineage is remarkably similar to the neural crest lineage. Previous studies have shown that migrating neural crest cells are multipotent (Baggiolini et al, 2015), and the ultimate cell fates are determined by their axial positions, as well as the migration timing and direction (Rocha et al, 2020).…”
Section: Multipotent Sclerotome Progenitors Are Fated By Local Signalsmentioning
confidence: 99%
“…Similarly, ectopic expression in the trunk neural tube of genes comprising a cardiac crest-specific subcircuit, Sox8, Tgif1 and Ets1, can redirect trunk neural crest cells grafted in place of ablated cardiac neural crest to migrate into the cardiac outflow tract, thus rescuing persistent truncus arteriosus (Gandhi et al, 2020). These two examples demonstrate that subtle differences in gene regulatory architectures can alter neural crest cell fate and account for axial level-specific differences between neural crest subpopulations; a more detailed discussion of neural crest regionalization along the AP axis is provided in the accompanying review by Rocha et al (2020).…”
Section: Quail-chick and Other Chimeraementioning
confidence: 97%