Infotainment comedy is the branch of infotainment that mixes current affairs content with comedy. “Infotainment” is a relatively new term, first cited by Krüger (1988); as a television trend, academics agree that it must have existed much earlier, with English-language examples such as Saturday Night Live (NBC, 1975) or That was the week that was (BBC, 1962). In Spain, the roots of infotainment lie in Caiga quien caiga (Telecinco, 1996), a precursor to satirical pseudojournalism (García-Avilés, 1999). Nowadays, there are programs that present current affairs with comedy, as in the case of El intermedio (La Sexta, 2006) or Todo es mentira (Cuatro, 2019). Owing to the continuous evolution of formats and their complex definition and classification by academics and professionals, it is worth considering whether audiences also interpret the different programs in different ways depending on their elements, given that they depend on an “intuitive understanding” (Reinemann et al., 2011; Otto et al., 2017) that stems from the habit of repeated consumption. This article presents the results of a reception study contrasting Spanish infotainment comedy professionals and their audiences to assess whether their impressions of these shows are similar or if, on the contrary, their hybrid nature is so changeable that they have come to interpret them in a very different way. The methodology involved ten discussion groups with a total of 87 viewers and 13 interviews with professionals from four programs: El intermedio, Todo es mentira, Ese programa del que usted me habla (La 2, 2019), and La resistencia (Movistar+, 2018). According to the statements collected, the results revealed that audiences and content creators show more points of divergence than concurrences, which means that the messages are interpreted differently from how they were intended.