From IBS to ME – The dysbiotic march hypothesis

Berstad, Arnold; Hauso, Olav; Berstad, K; Berstad, J

doi:10.1016/j.mehy.2020.109648

Cited by 10 publications

(14 citation statements)

References 44 publications

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“…Interestingly, the mode of delivery influences the amount of antibiotic resistance genes in the microbiome, with vaginally delivered infants appearing to be relatively protected against antibiotic resistance (150). Berstad and coworkers suggested with their three-set "dysbiotic march hypothesis" an explanation for the high comorbidity in ME/ CFS patients with IBS, as described above (192).…”

Section: Past Antibiotic Intake Hypothesis In Me/cfs Patientsmentioning

confidence: 99%

“…Another possible explanation is the “dysbiotic march hypothesis” from IBS to ME/CFS by Berstad and co-workers. They suggested a three-step progression where excessive use of antibiotics in childhood might lead to typical abdominal symptoms of IBS and, years later, to the development of chronic inflammatory diseases possibly including ME/CFS ( 192 ). A similar hypothesis was stated by Kuo et al., who showed a significantly increased risk in women of developing ME/CFS following Helicobacter pylori associated peptic ulcer disease in a recent retrospective cohort study ( 193 ).…”

Section: The Role Of the Gut Microbiome In Me/cfsmentioning

confidence: 99%

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The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

et al. 2022

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Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected, debilitating multi-systemic disease without diagnostic marker or therapy. Despite evidence for neurological, immunological, infectious, muscular and endocrine pathophysiological abnormalities, the etiology and a clear pathophysiology remains unclear. The gut microbiome gained much attention in the last decade with manifold implications in health and disease. Here we review the current state of knowledge on the interplay between ME/CFS and the microbiome, to identify potential diagnostic or interventional approaches, and propose areas where further research is needed. We iteratively selected and elaborated on key theories about a correlation between microbiome state and ME/CFS pathology, developing further hypotheses. Based on the literature we hypothesize that antibiotic use throughout life favours an intestinal microbiota composition which might be a risk factor for ME/CFS. Main proposed pathomechanisms include gut dysbiosis, altered gut-brain axis activity, increased gut permeability with concomitant bacterial translocation and reduced levels of short-chain-fatty acids, D-lactic acidosis, an abnormal tryptophan metabolism and low activity of the kynurenine pathway. We review options for microbiome manipulation in ME/CFS patients including probiotic and dietary interventions as well as fecal microbiota transplantations. Beyond increasing gut permeability and bacterial translocation, specific dysbiosis may modify fermentation products, affecting peripheral mitochondria. Considering the gut-brain axis we strongly suspect that the microbiome may contribute to neurocognitive impairments of ME/CFS patients. Further larger studies are needed, above all to clarify whether D-lactic acidosis and early-life antibiotic use may be part of ME/CFS etiology and what role changes in the tryptophan metabolism might play. An association between the gut microbiome and the disease ME/CFS is plausible. As causality remains unclear, we recommend longitudinal studies. Activity levels, bedridden hours and disease progression should be compared to antibiotic exposure, drug intakes and alterations in the composition of the microbiota. The therapeutic potential of fecal microbiota transfer and of targeted dietary interventions should be systematically evaluated.

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Section: Past Antibiotic Intake Hypothesis In Me/cfs Patientsmentioning

confidence: 99%

Section: The Role Of the Gut Microbiome In Me/cfsmentioning

confidence: 99%

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

et al. 2022

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“…IBS is another largely overlapping syndrome with both ME/CFS and FM but metabolic profiles are distinct in ME/CFS and ME/CFS with IBS subgroups (176). Some authors hypothesize IBS could be considered an initial symptom of ME/CFS, as they reported that 65% of IBS patients followed up developed ME (177). Authors of a co-twin control study found significant associations between CFS and FM, IBS, chronic pelvic pain, multiple chemical sensitivities, and temporomandibular disorder.…”

Section: Common Comorbidities In Me/cfsmentioning

confidence: 99%

How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS

et al. 2020

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“…In 1915, Walter Alwarez of the Mayo Clinic popularized the term "functional dyspepsia", the most common disorder from the group of functional disorders. Reported dyspeptic ailments are not correlated with specific physiological disorders, although a relationship has been found between the symptoms of premature satiety and disorders of gastric accommodation, in gastroduodenitis, genetic studies are also carried out, or links between bacterial inflammation of the upper and lower gastrointestinal tract and functional disorders [17][18][19][20][21][22][23][24]. There are no objective diagnostic tools; the symptomatic criteria for functional disorders based on the Roman Criteria are expert consensus excluding organic causes of ailments [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Selected personality traits and emotional disorders of women diagnosed with gastrointestinal disease – a pilot study

Piotrowicz¹,

Rudnik²,

Bidzan³

et al. 2023

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Introduction:There are many studies on the influence of psychological factors in the appearance of symptoms and their treatment among gastroenterological patients. It is increasingly indicated that these factors are of great importance also for the quality of life of people struggling with a chronic disease.Aim: To evaluate personality traits and emotional disorders in female patients with gastrointestinal conditions such as functional dyspepsia (FD), irritable bowel syndrome (IBS), or inflammatory bowel disease (IBD).Material and methods: The sample of 28 patients was verified in terms of the disease using the GAST questionnaire and assessed by personality questionnaires and psychological tests: the Spielberger State-Trait Anxiety Inventory (STAI), EAS Temperament Survey, Eysenck Personality Inventory (EPQ-R), Coping Inventory for Stressful Situations (CISS); Beliefs about Pain Control Questionnaire (BPCQ), General Self-efficacy Scale (GSES), and Satisfaction with Life Scale (SWLS).Results: The control group was recruited from female university students declaring full health. The conducted statistical analysis showed that there is a significant relationship between personality traits, psychological predispositions, and both the experience of illness and satisfaction with life among this specific group of patients.Conclusions: This pilot study demonstrated the need for a personalized approach to gastroenterological patients, also based on their personality characteristics. Such an approach may increase the effectiveness of therapy and bring benefits in long-term treatment.

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From IBS to ME – The dysbiotic march hypothesis

Cited by 10 publications

References 44 publications

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS

Selected personality traits and emotional disorders of women diagnosed with gastrointestinal disease – a pilot study

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