2015
DOI: 10.1186/s13148-015-0068-2
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From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

Abstract: The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, arthritis, and dementia. The heterogeneity in biological aging, chronological age, and aging-associated disorders in humans have been ascribed to different genetic and environmental factors (i.e., diet, pollution, stress) that are closely linked to socioeconomic … Show more

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Cited by 160 publications
(106 citation statements)
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References 340 publications
(296 reference statements)
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“…88 In colorectal cancer cells, luteolin (3′,4′,5,7-tetrahydroxyflavone) caused apoptosis by downregulating UHRF1. 89 Limoniastrum guyonianum aqueous gall extract and luteolin arrested HeLa cells in G2 phase and induced apoptosis through inhibition of UHRF1/DNMT1 tandem expression, followed by an upregulation of p16 INK4A .…”
Section: Modulation Of Uhrf1 By Natural Polyphenolsmentioning
confidence: 99%
“…88 In colorectal cancer cells, luteolin (3′,4′,5,7-tetrahydroxyflavone) caused apoptosis by downregulating UHRF1. 89 Limoniastrum guyonianum aqueous gall extract and luteolin arrested HeLa cells in G2 phase and induced apoptosis through inhibition of UHRF1/DNMT1 tandem expression, followed by an upregulation of p16 INK4A .…”
Section: Modulation Of Uhrf1 By Natural Polyphenolsmentioning
confidence: 99%
“…For example, food components may interact with epigenetic factors with powerful protective and preventive potentials against inflammation in aging and age-related diseases [18]. Moreover, circadian rhythms have profound effects on xenobiotic metabolism and detoxification processes [19].…”
Section: Editorial Yanmentioning
confidence: 99%
“…In addition, diet is believed to have a major influence on inflammatory signaling. This could regulate metabolic pathways and bioenergetics in a way that could be translated into a stable epigenetic pattern of gene expression (36). Our study population was from Black Sea region of Turkey, which may be a factor in terms of dietary habits and metabolic features of the disease.…”
Section: Discussionmentioning
confidence: 99%