As digitally enabled information systems play an increasingly central role in culture and economics, their negative consequences have become apparent. This guest editorial addresses the urgent need for information scientists to take a more deliberate stance in designing and guiding the evolution of these systems. We propose a framework for conceptualizing “healthier information ecosystems” by drawing on theories from complex systems and ecological research, grounded in a value‐oriented approach. The article reviews key concepts from systems science, complex systems, and ecology, with a focus on ecosystem and adaptation research. These perspectives offer analytical approaches for decomposing information ecosystems and provide a foundation for understanding “health” in the context of evolving, open systems. Unlike natural ecosystems, information ecosystems must be evaluated according to human values; thus, we articulate a set of values as a starting point for defining health in this context. By introducing insights from beyond the field of information systems, we aim to instigate scholarly dialog, connect prior work in new ways, and reveal new opportunities for research and intervention. This connective and argumentative contribution is intended to guide future research and identify solutions to the proliferating problems in our current information ecosystems.