From interaction of lipidic vehicles with intestinal epithelial cell membranes to the formation and secretion of chylomicrons

Detergent-Resistant Microdomains Determine the Localization of σ-1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

“…As a metabolic intermediate of the rapid ceramide biosynthesis, sphingosine is kept at a considerably low level in the cell, especially under unstressed conditions (Spiegel and Milstien, 2003). Sphingosine is physicochemically categorized as a class III lipid (i.e., a swelling amphiphile that possesses strong polar groups of the aminoalcohol head) that renders the molecule soluble in water at low concentrations (Shen et al, 2001). Furthermore, a previous study showed that sphingosine (at higher concentrations) is taken up by the membrane via a passive diffusion mechanism independent of lipid raft integrity (Garmy et al, 2005).…”

Intestinal fatty acid binding protein and microsomal triglyceride transfer protein polymorphisms in French-Canadian youth

“…Further studies are required to clarify these hypotheses, especially because targeted gene disruption of FABP2 in mice did not compromise dietary fat absorption in vivo but was associated with the development of insulin resistance (34). It remains possible that other FABPs or lipid carriers are capable of compensating for the deficient function assumed by the disrupted gene (35,36). The FABP2 Thr/Thr genotype was associated with a much steeper increase in TC, LDL-C, and apoB in parallel to TG concentrations than the Thr/Ala and Ala/Ala genotypes.…”

Digestion and absorption of olive oil

“…This contraction causes the antral contents moved back from the terminal antrum into the corpus. Both actions, grinding and retro-propulsion of antral contents, provide most of mechanical action involved in the pre-intestinal emulsification of triglycerides (Shen et al, 2001). These processes are an important requisite for efficient hydrolysis by pancreatic lipase in the duodenum.…”

“…Lipid emulsion enters the intestine as fine droplets less than 0.5 µm in diameter (Shen et al, 2001). The smaller size increases proportionally the lipid surface exposed to pancreatic lipase (Blow, 1991).…”

“…Today is well known that micelles and liposomes coexist in the intestinal lumen, but since they are constantly exchanging sn-2 MG and FFA, their relative roles in lipid transport are still unclear (Shen et al, 2001). Lipid carrying particles able to arrive to the unstirred water layer cannot be larger than the width of the gaps in the microvilli themselves.…”