From Killing Bacteria to Destroying Cancer Cells: 20 Years of Plasma Medicine

Laroussi, Mounir

doi:10.1002/ppap.201400152

Cited by 127 publications

(92 citation statements)

References 27 publications

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“…Experimental evidence has shown that LTP does indeed affect cells underneath the tissue surface but what remains unclear is how. One possible explanation is what is referred to as the "bystander effect," which implies that there are chemical signals sent by the cells on the surface (in contact with plasma) to cells in the layer below [41]. These signals would trigger reactions similar to those occurring at the cells on the surface, including the onset of apoptosis.…”

Section: Penetration Of Rons In Tissuesmentioning

confidence: 99%

Plasma Medicine: A Brief Introduction

Laroussi

2018

Plasma

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179

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This mini review is to introduce the readers of Plasma to the field of plasma medicine. This is a multidisciplinary field of research at the intersection of physics, engineering, biology and medicine. Plasma medicine is only about two decades old, but the research community active in this emerging field has grown tremendously in the last few years. Today, research is being conducted on a number of applications including wound healing and cancer treatment. Although a lot of knowledge has been created and our understanding of the fundamental mechanisms that play important roles in the interaction between low temperature plasma and biological cells and tissues has greatly expanded, much remains to be done to get a thorough and detailed picture of all the physical and biochemical processes that enter into play.

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Section: Penetration Of Rons In Tissuesmentioning

confidence: 99%

Plasma Medicine: A Brief Introduction

Laroussi

2018

Plasma

Self Cite

179

122

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“…the destruction of biofilms [15] and tumours [16] in the order of 10s of micrometres to millimetres in thickness. APPJ deactivation of biofilms and tumours are often explained by surface cell layers transmitting signals deeper within tissue through cell-to-cell communication [17,18]. Using a synthetic tissue and cell model, we have shown that a He APPJ can directly interact with cells in the sub-surface of tissue (~150 m) [19].…”

Section: Introductionmentioning

confidence: 99%

In-situ UV Absorption Spectroscopy for Monitoring Transport of Plasma Reactive Species through Agarose as Surrogate for Tissue

Szili

Gaur

et al. 2015

J. Photopol. Sci. Technol.

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We demonstrated the efficacy of using a simple experimental approach, involving UV absorption spectroscopy, to monitor the transport of reactive oxygen and nitrogen species (RONS) through an agarose film (as surrogate for real tissue) into deionized (DI) water. The experiment involved placing a 4 mm thick agarose film over a quartz cuvette filled with DI water. The agarose film was exposed to a non-thermal, He atmospheric-pressure plasma jet (APPJ) and the UV absorption of the DI water was recorded in real-time. Our results indicate an accumulation of RONS within the agarose film during APPJ exposure and a subsequent time-lapsed release of RONS into the DI water. Curve fitting of the UV spectra suggested the APPJ transported and / or generated at least four RONS (NaNO 2 , HNO 3 , H 2 O 2 and O 2 ) through the 4 mm thick agarose film. Our approach of analyzing the delivery depth of RONS through synthetic tissue targets might find use in the future development of APPJ medical therapies and for improving our understanding of APPJ interactions with soft tissue.

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“…Atmospheric-pressure plasmas interacting with air and/or water vapor provide a rich source of RONS [62], and could play an important role in oxidation-reduction biology and medicine as previously reviewed [47]. It has been experimentally shown how RONS might intervene in cellular signaling processes to target the destruction of bacteria and or cancerous cells [68][69][70][71][72]. It is now widely accepted that atmospheric-pressure plasmas can be used to deliver RONS into solution or onto a soft medium (e.g., on an agar plate or on living tissue) to regulate cellular functions.…”

Section: Future Directions In the Use Of Microplasma Arrays To Functimentioning

confidence: 99%

Microplasma Array Patterning of Reactive Oxygen and Nitrogen Species onto Polystyrene

Szili

Dedrick

et al. 2017

Front. Phys.

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We investigate an approach for the patterning of reactive oxygen and nitrogen species (RONS) onto polystyrene using atmospheric-pressure microplasma arrays. The spectrally integrated and time-resolved optical emission from the array is characterized with respect to the applied voltage, applied-voltage frequency and pressure; and the array is used to achieve spatially resolved modification of polystyrene at three pressures: 500, 760, and 1000 Torr. As determined by time-of-flight secondary ion mass spectrometry (ToF-SIMS), regions over which surface modification occurs are clearly restricted to areas that are exposed to individual microplasma cavities. Analysis of the negative-ion ToF-SIMS mass spectra from the center of the modified microspots shows that the level of oxidation is dependent on the operating pressure, and closely correlated with the spatial distribution of the optical emission. The functional groups that are generated by the microplasma array on the polystyrene surface are shown to readily participate in an oxidative reaction in phosphate buffered saline solution (pH 7.4). Patterns of oxidized and chemically reactive functionalities could potentially be applied to the future development of biomaterial surfaces, where spatial control over biomolecule or cell function is needed.

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From Killing Bacteria to Destroying Cancer Cells: 20 Years of Plasma Medicine

Abstract: This is an essay that briefly reviews and discusses the application of low temperature plasma (LTP) to kill cancer cells. Some historical background is given and the views and opinions of the author about the present and future of the field are presented.

Cited by 127 publications

References 27 publications

Plasma Medicine: A Brief Introduction

Plasma Medicine: A Brief Introduction

In-situ UV Absorption Spectroscopy for Monitoring Transport of Plasma Reactive Species through Agarose as Surrogate for Tissue

Microplasma Array Patterning of Reactive Oxygen and Nitrogen Species onto Polystyrene

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