In this article, we draw on science and technology studies literature on care practices to analyse school nurses’ work with human papillomavirus (HPV) vaccination in schools, in the context of a new vaccination policy including all children in the fifth grade in Sweden. Drawing on 21 interviews with school nurses working in municipalities across a larger Swedish region, we focus on the mundane work of handling the vaccination and supporting the children while they are being vaccinated. We utilise the notion of ‘modes of doing good’ to analyse routines and ideals oriented towards specific, and sometimes contradictory, forms of ‘good care’ in HPV vaccination practice. Two modes of doing good are identified: the vaccination as a caring for ‘the flow’ of children getting vaccinated and the vaccination as a caring about the specific child. We analyse three ‘child subjects’ alongside these modes: the informed and already prepared child, the anxious child, and the specific child. By identifying tensions and interferences between different child subjects and modes of doing good, we discuss possible consequences of our findings for how HPV vaccination is envisioned and conceptualised in social science research and in policy settings.