From magnetotactic bacteria to hollow spirilla-shaped silica containing a magnetic chain

Baumgartner, Jens; Lesevic, Paul; Kumari, Monika; Halbmair, Karin; Bennet, Mathieu; Körnig, André; Widdrat, Marc; Andert, Janet; Wollgarten, Markus; Bertinetti, Luca; Strauch, Peter; Hirt, Ann M.; Faivre, Damien

doi:10.1039/c2ra20911j

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…Biological as well as biomimetic materials such as viruses, [1] bacteria, [2] peptides, [3] DNA, [4] or proteins [5] have been used as templates for the mineralization of inorganic particles or, alternatively, for their binding and organization in a wide variety of different geometries. The variety of available scaffolds is appealing as it enables to design functional materials with different characteristics such as dimensions and material specificity.…”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Organization: Protein Template, Biological Recognition Sites, and Nanoparticles

Jehle

Valverde-Tercedor

Reichel

et al. 2016

Adv Materials Inter

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Nanoparticles and their assemblies exhibit properties that can be used for a wide range of applications. However, creating multifunctional assemblies has remained challenging. Inspired by magnetotactic bacteria, genetically engineered single building blocks from magnetosome chains are used and complemented by additional components to form fluorescent assemblies of nanoparticles of varying types. This strategy is illustrated by the use of a protein from magnetotactic bacteria (MamK) known to form filaments in vivo and in vitro. A fusion protein of MamK and the fluorescent protein mCherry is recombinantly expressed and isolated using a hexahistidine tag that is subsequently used to bind functionalized gold nanoparticles to polymerized MamK_mCherry_His6 filaments. The versatility of this modular approach is further exemplified by the concomitant addition of biological or synthetic magnetic nanoparticles functionalized with a nanobody directed against mCherry. The as‐formed structures are fluorescent and can be actuated by an external magnetic field. This study shows again how nature's strategies can be applied for designing multifunctional materials.

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Section: Introductionmentioning

confidence: 99%

Genetically Engineered Organization: Protein Template, Biological Recognition Sites, and Nanoparticles

Jehle

Valverde-Tercedor

Reichel

et al. 2016

Adv Materials Inter

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Biogenic Approaches for SiO₂Nanostructures: Exploring the Sustainable Platform of Nanofabrication

Hariram¹,

Vishnukumar²,

Vivekanandhan³

2018

Green and Sustainable Advanced Materials

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Nature-inspired miniaturized magnetic soft robotic swimmers

Pramanik,

Verstappen,

Onck

2024

Applied Physics Reviews

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State-of-the-art biomedical applications such as targeted drug delivery and laparoscopic surgery are extremely challenging because of the small length scales, the requirements of wireless manipulation, operational accuracy, and precise localization. In this regard, miniaturized magnetic soft robotic swimmers (MSRS) are attractive candidates since they offer a contactless mode of operation for precise path maneuvering. Inspired by nature, researchers have designed these small-scale intelligent machines to demonstrate enhanced swimming performance through viscous fluidic media using different modes of propulsion. In this review paper, we identify and classify nature-inspired basic swimming modes that have been optimized over large evolutionary timescales. For example, ciliary swimmers like Paramecium and Coleps are covered with tiny hairlike filaments (cilia) that beat rhythmically using coordinated wave movements for propulsion and to gather food. Undulatory swimmers such as spermatozoa and midge larvae use traveling body waves to push the surrounding fluid for effective propulsion through highly viscous environments. Helical swimmers like bacteria rotate their slender whiskers (flagella) for locomotion through stagnant viscid fluids. Essentially, all the three modes of swimming employ nonreciprocal motion to achieve spatial asymmetry. We provide a mechanistic understanding of magnetic-field-induced spatiotemporal symmetry-breaking principles adopted by MSRS for the effective propulsion at such small length scales. Furthermore, theoretical and computational tools that can precisely predict the magnetically driven large deformation fluid–structure interaction of these MSRS are discussed. Here, we present a holistic descriptive review of the recent developments in these smart material systems covering the wide spectrum of their fabrication techniques, nature-inspired design, biomedical applications, swimming strategies, magnetic actuation, and modeling approaches. Finally, we present the future prospects of these promising material systems. Specifically, synchronous tracking and noninvasive imaging of these external agents during in vivo clinical applications still remains a daunting task. Furthermore, their experimental demonstrations have mostly been limited to in vitro and ex vivo phantom models where the dynamics of the testing conditions are quite different compared the in vivo conditions. Additionally, multi-shape morphing and multi-stimuli-responsive modalities of these active structures demand further advancements in 4D printing avenues. Their multi-state configuration as an active solid-fluid continuum would require the development of multi-scale models. Eventually, adding multiple levels of intelligence would enhance their adaptivity, functionalities, and reliability during critical biomedical applications.

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From magnetotactic bacteria to hollow spirilla-shaped silica containing a magnetic chain

Cited by 4 publications

References 25 publications

Genetically Engineered Organization: Protein Template, Biological Recognition Sites, and Nanoparticles

Genetically Engineered Organization: Protein Template, Biological Recognition Sites, and Nanoparticles

Biogenic Approaches for SiO₂Nanostructures: Exploring the Sustainable Platform of Nanofabrication

Nature-inspired miniaturized magnetic soft robotic swimmers

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From magnetotactic bacteria to hollow spirilla-shaped silica containing a magnetic chain

Cited by 4 publications

References 25 publications

Genetically Engineered Organization: Protein Template, Biological Recognition Sites, and Nanoparticles

Genetically Engineered Organization: Protein Template, Biological Recognition Sites, and Nanoparticles

Biogenic Approaches for SiO2Nanostructures: Exploring the Sustainable Platform of Nanofabrication

Nature-inspired miniaturized magnetic soft robotic swimmers

Contact Info

Product

Resources

About

Biogenic Approaches for SiO₂Nanostructures: Exploring the Sustainable Platform of Nanofabrication