Background Self-compassion has been considered beneficial in overcoming negative self-assessment due to inadequate coping that increases vulnerability to significant distress among undergraduate students in emerging adulthood. Methods Subjects were 552 Indonesian undergraduate students from Diponegoro University, Indonesia (M Age = 20.03; SD Age = 1,022). Sex and age category were identified for further analysis. The measurements used the Self-Compassion Scale (SCS) and General Health Questionnaire-12 (GHQ-12). The GHQ-12 also measures psychological morbidity in three dimensions, i.e. social dysfunction, anxiety and depression symptoms, and loss of confidence. Data were analyzed using Spearman's rho. Additional analyzes using the Mann-Whitney U Test and descriptive statistics were also performed. Results Self-compassion had a significant negative relation with distress. Self-compassion was significantly related to all dimensions of distress, i.e. loss of confidence, anxiety and depression symptoms, and social dysfunction (from largest to smallest respectively). The correlation between self-compassion and distress in men was higher than women, both were significant. The correlation between those two constructs in late adolescence and early adulthood were also significant. Both sex and age did not significantly predict self-compassion and distress. Conclusion The existence of self-compassion could predict a lower level of distress both in general and based on its dimensions, as well as correlations based on sex and age categories. A higher correlation in men may be of concern, while the absence of a marked difference in the correlation by age category could be due to the effect of small age variation in both age categories that was still in the emerging adult period. This was also supported by a non-significant difference of each variable across sex and age category. Discussions based on cultural values were also considered.