From Melanocytes to Melanoma Cells: Characterization of the Malignant Transformation by Four Distinctly Different Melanin Fluorescence Spectra (Review)

Leupold, D.; Hofmann, Maja; Forschner, Andrea; Wessler, Gerd; Haenssle, Holger A.

doi:10.3390/ijms22105265

Cited by 14 publications

(9 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As to the role of additional fluorophores, it is to recall that the weak fluorescence of melanin detected by dermatofluoroscopy, based on two-photon excitation non-linear spectroscopy, has been shown to discriminate melanocytes from melanoma cells. This finding has been suggested as a promising valuable support for the in situ diagnosis of skin malignancy with additional perspectives for manyfold application in melanin research in technology and biological science [323].…”

Section: Normal and Altered Cell And Tissuesmentioning

confidence: 71%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

View full text Add to dashboard Cite

Organisms belonging to all life kingdoms may have the natural capacity to fluoresce. Autofluorescence events depend on the presence of natural biomolecules, namely endogenous fluorophores, with suitable chemical properties in terms of conjugated double bonds, aromatic or more complex structures with oxidized and crosslinked bonds, ensuring an energy status able to permit electronic transitions matching with the energy of light in the UV-visible-near-IR spectral range. Emission of light from biological substrates has been reported since a long time, inspiring unceasing and countless studies. Early notes on autofluorescence of vegetables have been soon followed by attention to animals. Investigations on full living organisms from the wild environment have been driven prevalently by ecological and taxonomical purposes, while studies on cells, tissues and organs have been mainly promoted by diagnostic aims. Interest in autofluorescence is also growing as a sensing biomarker in food production and in more various industrial processes. The associated technological advances have supported investigations ranging from the pure photochemical characterization of specific endogenous fluorophores to their possible functional meanings and biological relevance, making fluorescence a valuable intrinsic biomarker for industrial and diagnostic applications, in a sort of real time, in situ biochemical analysis. This review aims to provide a wide-ranging report on the most investigated natural fluorescing biomolecules, from microorganisms to plants and animals of different taxonomic degrees, with their biological, environmental or biomedical issues relevant for the human health. Hence, some notes in the different sections dealing with different biological subject are also interlaced with human related issues. Light based events in biological subjects have inspired an almost countless literature, making it almost impossible to recall here all associated published works, forcing to apologize for the overlooked reports. This Review is thus proposed as an inspiring source for Readers, addressing them to additional literature for an expanded information on specific topics of more interest.

show abstract

Section: Normal and Altered Cell And Tissuesmentioning

confidence: 71%

Light and Autofluorescence, Multitasking Features in Living Organisms

Croce

2021

Photochem

View full text Add to dashboard Cite

show abstract

“…It has been traditionally known that skin pigmentation is the predominant factor protecting melanocytes and other epidermal cells from UV-induced carcinogenesis [ 68 , 77 ]. Additionally, recent studies suggest the possible implication of melanin in the behavior of malignant melanoma, the most aggressive and lethal skin cancer type [ 78 , 79 ].…”

Section: Therapeutic Propertiesmentioning

confidence: 99%

Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review

Marcovici

Coricovac

Pînzaru

et al. 2022

Cancers

View full text Add to dashboard Cite

Cancer poses an ongoing global challenge, despite the substantial progress made in the prevention, diagnosis, and treatment of the disease. The existing therapeutic methods remain limited by undesirable outcomes such as systemic toxicity and lack of specificity or long-term efficacy, although innovative alternatives are being continuously investigated. By offering a means for the targeted delivery of therapeutics, nanotechnology (NT) has emerged as a state-of-the-art solution for augmenting the efficiency of currently available cancer therapies while combating their drawbacks. Melanin, a polymeric pigment of natural origin that is widely spread among many living organisms, became a promising candidate for NT-based cancer treatment owing to its unique physicochemical properties (e.g., high biocompatibility, redox behavior, light absorption, chelating ability) and innate antioxidant, photoprotective, anti-inflammatory, and antitumor effects. The latest research on melanin and melanin-like nanoparticles has extended considerably on many fronts, allowing not only efficient cancer treatments via both traditional and modern methods, but also early disease detection and diagnosis. The current paper provides an updated insight into the applicability of melanin in cancer therapy as antitumor agent, molecular target, and delivery nanoplatform.

show abstract

“…This method is able to specifically detect melanin fluorescence without interference from background autofluorescence. As a diagnostic method, dermatofluoroscopy machines have been made commercially available [ 158 ], but further research is ongoing to develop the method.…”

Section: Screening and Image-based Approaches To Secondary Preventionmentioning

confidence: 99%

Etiologies of Melanoma Development and Prevention Measures: A Review of the Current Evidence

Djavid

Stonesifer

Fullerton

et al. 2021

Cancers

View full text Add to dashboard Cite

(1) Melanoma is the most aggressive dermatologic malignancy, with an estimated 106,110 new cases to be diagnosed in 2021. The annual incidence rates continue to climb, which underscores the critical importance of improving the methods to prevent this disease. The interventions to assist with melanoma prevention vary and typically include measures such as UV avoidance and the use of protective clothing, sunscreen, and other chemopreventive agents. However, the evidence is mixed surrounding the use of these and other interventions. This review discusses the heritable etiologies underlying melanoma development before delving into the data surrounding the preventive methods highlighted above. (2) A comprehensive literature review was performed to identify the clinical trials, observational studies, and meta-analyses pertinent to melanoma prevention and incidence. Online resources were queried to identify epidemiologic and clinical trial information. (3) Evidence exists to support population-wide screening programs, the proper use of sunscreen, and community-targeted measures in the prevention of melanoma. Clinical evidence for the majority of the proposed preventive chemotherapeutics is presently minimal but continues to evolve. (4) Further study of these chemotherapeutics, as well as improvement of techniques in artificial intelligence and imaging techniques for melanoma screening, is warranted for continued improvement of melanoma prevention.

show abstract

From Melanocytes to Melanoma Cells: Characterization of the Malignant Transformation by Four Distinctly Different Melanin Fluorescence Spectra (Review)

Cited by 14 publications

References 37 publications

Light and Autofluorescence, Multitasking Features in Living Organisms

Light and Autofluorescence, Multitasking Features in Living Organisms

Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review

Etiologies of Melanoma Development and Prevention Measures: A Review of the Current Evidence

Contact Info

Product

Resources

About