From Nanofibers to Nanorods: Nanostructure of Peptide‐Drug Conjugates Regulated by Polypeptide‐PEG Derivative and Enhanced Antitumor Effect

Chen, Rui; Wang, Jingjing; Qian, Chen; Ji, Yujie; Zhu, Chenlu; Wu, Li; Li, Weidong; Bi, Xiaolin; Wang, Yutong; Cao, Gang; Chen, Zhipeng

doi:10.1002/adfm.201806058

Cited by 22 publications

(11 citation statements)

References 23 publications

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“…Among these, both sodium azide and chlorpromazine decreased the cellular uptake of PQC NFs, which implicated that PQC NFs entered cells mainly through clathrin-mediated endocytosis, rather than caveolae-mediated endocytosis (genistein) or micropinocytosis (amiloride) (Figure 3d and Figure S12, Supporting information). [30]…”

Section: Cellular Uptake and Endocytosismentioning

confidence: 99%

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Lin

et al. 2020

Adv Funct Materials

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Photodynamic therapy (PDT) has emerged as an attractive alternative in cancer therapy, but its therapeutic effects are limited by the nonselective subcellular localization and poor intratumoral retention of small‐molecule photosensitizes. Here a fiber‐forming nanophotosensitizer (PQC NF) that is composed of mitochondria targeting small molecules of amphiphilicity is reported. Harnessing the specific mitochondria targeting, the light‐activated PQC NFs produce approximately 110‐fold higher amount of reactive oxygen species in cells than free photosensitizers and can dramatically induce mitochondrial disruption to trigger intense apoptosis, showing 20–50 times better in vitro anticancer potency than traditional photosensitizers. As fiber‐shaped nanomaterials, PQC NFs also demonstrated a long‐term retention in tumor sites, solving the challenge of rapid clearance of small‐molecule photosensitizers from tumors. With these advantages, PQC NFs achieve a 100% complete cure rate in both subcutaneous and orthotopic oral cancer models with the administration of only a single dose. This type of single small molecule‐assembled mitochondria targeting nanofibers offers an advantageous strategy to improve the in vivo therapeutic effects of conventional PDT.

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Section: Cellular Uptake and Endocytosismentioning

confidence: 99%

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Lin

et al. 2020

Adv Funct Materials

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“…To develop outstanding drug delivery system for intravenous administration, short nanorods ( Figure 16) were fabricated based on ionic coassembly of doxorubicin (DOX) conjugated KGFRWR (P67) and PEGylated poly-Glu (P68) with galactosamine terminals. [148] The obtained nanorods possessed a core-shell nanostructure with P67 micelles as core and P68 covered on the surface as the shell through electrostatic attraction. The PEG corona of P68 offered the particular advantages in prolonging circulation time, reducing body clearance, and enhancing bioavailability.…”

Section: Ionic Coassembly Between Cationic Peptides and Anionic Peptidesmentioning

confidence: 99%

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

Xie

Zheng

2020

Macromol. Rapid Commun.

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innovative insight into understanding the properties of the material systems beyond molecular level. [6-8] Through the last decades, supramolecular chemistry has deeply permeated and fused with biology and materials science, and has gradually growth into an interdisciplinary platform for the creation of self-assembled systems with extraordinary properties. [9-12] Among the numerous systems, self-assembled peptide is one of the most important branches, because of its rich chemical diversity, versatile characters, inherent biocompatibility, and bioactivity. [13-15] Specifically, the natural or chemically engineered amino acids encoded in the sequence of peptide molecules enable the formation of customizable secondary structures, the cooperative interactions between main chains and side chains of peptide molecules can be further leveraged to produce hierarchical nanostructures [16-22] and important biofunctions, such as drug delivery, [23-25] tissue engineering, [26-28] regenerative medicine, [29-31] and biomineralization. [32-35] Moreover, many studies have disclosed that self-assembled peptide nanostructures can offer higher performance (catalytic, therapeutic, targeting, etc.) than peptide itself. [36-42] For those reasons, peptide self-assembly has been recognized as a subject of great importance in supramolecular chemistry, biology, and nanotechnology, and the breadth and depth of peptide selfassemblies have been documented and demonstrated in several excellent reviews. [43-51] Besides the self-assembly of unimolecular peptides, multicomponent coassembly between peptides and other building blocks has recently become increasingly prevalent, as the modular approach offers a simple and effective way to arrive at supramolecular materials with wide structural complexity and value-added properties for multiple tasks applications. [52-56] This integrated characteristic further stimulates researchers to explore the scope of peptide coassembly with the aim of expanding the space of functional utility. To selectively form the multicomponent nanostructures, the interplay of the driving forces should be energetically much more favorable for strengthening the coassembly of distinct components than the self-sorting of the same type of components. [57-59] Following this design criteria, the introduction of complementary noncovalent interactions into the multicomponent systems is Peptide assembly has been extensively exploited as a promising platform for the creation of hierarchical nanostructures and tailor-made bioactive materials. Ionic coassembly of cationic peptides and anionic species is paving the way to provide particularly important contribution to this topic. In this review, the recent progress of ionic coassembly soft materials derived from the electrostatic coupling between cationic peptides and anionic species in aqueous solution is systematically summarized. The presentation of this review starts from a brief background on the general importance and advantages of peptide-based ionic coassembly. After that, divers...

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“…Enzyme-triggered self-assembly and hydrogelation of linear peptides have attracted a great deal of attention due to their good biocompatibility (Qin et al, 2013;Vigier-Carrière et al, 2015;Abbas et al, 2017;Wang et al, 2017). Upon undergoing self-assembly at sufficient concentration, peptide-based nanofibers form an entangled network which reduces the flow of solvents, leading to the hydrogel state (Nguyen et al, 2018;King et al, 2016;O'Leary et al, 2011;Chen et al, 2019). Such enzyme-triggered peptide self-assembly provides an efficient and practical method for controlling nanofiber self-assembly and hydrogelation as a function of environment (Rudra et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

Yang¹,

Zhao

Peng³

et al. 2022

Front. Pharmacol.

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Chemoresistance is a major therapeutic obstacle in the treatment of breast cancer. Therefore, how to overcome chemoresistance is a problem to be solved. Here, a glutathione (GSH)/cathepsin B (CB) dual-controlled nanomedicine formed by cyclic disulfide-bridged peptide (cyclic-1a) as a potent anticancer agent is reported. Under the sequential treatment of GSH and CB, cyclic-1a can efficiently self-assemble into nanofibers. In vitro studies show that cyclic-1a promotes the apoptosis of MCF-7/DOX cells by inducing the cleavages of caspase-3 and PARP. In vivo studies confirm that cyclic-1a significantly inhibits the progression of MCF-7/DOX cells-derived xenograft in nude mice, with no obvious adverse reactions. This study provides a paradigm of GSH/CB dual-controlled nanomedicine for high-efficacy and low-toxic DOX-resistant breast cancer therapy.

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From Nanofibers to Nanorods: Nanostructure of Peptide‐Drug Conjugates Regulated by Polypeptide‐PEG Derivative and Enhanced Antitumor Effect

Cited by 22 publications

References 23 publications

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

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