From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer

Bischof, John C.; Diller, Kenneth R.

doi:10.1146/annurev-bioeng-071516-044532

Cited by 27 publications

(13 citation statements)

References 154 publications

(192 reference statements)

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“…The laser heating of gold nanoparticles (GNS) is increasingly applied for the controlled heating of biological systems, with applications ranging in scale from the molecular to bulk tissue 1 – 3 . The key advantage of laser GNS heating is extremely efficient light-to-heat (photon energy-to-thermal energy) conversion and consequently, extremely rapid heating rates.…”

Section: Introductionmentioning

confidence: 99%

“…The key advantage of laser GNS heating is extremely efficient light-to-heat (photon energy-to-thermal energy) conversion and consequently, extremely rapid heating rates. For reference, iron oxide nanoparticles have been used for decades in cancer treatments, and typically have specific absorption rates in the 100’s of W/mg Fe; whereas laser heating of GNS can yield specific absorption rates that are orders of magnitude higher on a per weight bases: 100’s W/µg Au 1 , 4 . In addition, GNS surface chemistry is well-developed, enabling tailored coating and functionalization for biological applications 5 , 6 .…”

Section: Introductionmentioning

confidence: 99%

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Aggregation affects optical properties and photothermal heating of gold nanospheres

Wang

Gao

Han

et al. 2021

Sci Rep

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Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS aggregation affects heating have been carried out. We posit here that aggregation, which can occur within some biological systems, will significantly impact the optical and therefore heating properties of GNS. To address this, we employed discrete dipole approximation (DDA) simulations, Ultraviolet–Visible spectroscopy (UV–Vis) and laser calorimetry on GNS primary particles with diameters (5, 16, 30 nm) and their aggregates that contain 2 to 30 GNS particles. DDA shows that aggregation can reduce the extinction cross-section on a per particle basis by 17–28%. Experimental measurement by UV–Vis and laser calorimetry on aggregates also show up to a 25% reduction in extinction coefficient and significantly lower heating (~ 10%) compared to dispersed GNS. In addition, comparison of select aggregates shows even larger extinction cross section drops in sparse vs. dense aggregates. This work shows that GNS aggregation can change optical properties and reduce heating and provides a new framework for exploring this effect during laser heating of nanomaterial solutions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aggregation affects optical properties and photothermal heating of gold nanospheres

Wang

Gao

Han

et al. 2021

Sci Rep

Self Cite

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“…If the heat generation rate is not sufficiently large to meet the critical warming rate of the cryopreservation agent, large thermal stresses will form across the tissue/organ. These thermal stresses induce large the mechanical stresses that can cause mechanical cracks, and ultimately destroying the cryopreserved tissue/organ [165,166]. Spherical superparamagnetic nanoparticles have shown promising results as they meet the critical warming rate of VS55, a commonly used cryopreservation agent.…”

Section: Cryopreservationmentioning

confidence: 99%

A Guideline for Effectively Synthesizing and Characterizing Magnetic Nanoparticles for Advancing Nanobiotechnology: A Review

Kouhpanji

Stadler

2020

Sensors

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The remarkable multimodal functionalities of magnetic nanoparticles, conferred by their size and morphology, are very important in resolving challenges slowing the progression of nanobiotechnology. The rapid and revolutionary expansion of magnetic nanoparticles in nanobiotechnology, especially in nanomedicine and therapeutics, demands an overview of the current state of the art for synthesizing and characterizing magnetic nanoparticles. In this review, we explain the synthesis routes for tailoring the size, morphology, composition, and magnetic properties of the magnetic nanoparticles. The pros and cons of the most popularly used characterization techniques for determining the aforementioned parameters, with particular focus on nanomedicine and biosensing applications, are discussed. Moreover, we provide numerous biomedical applications and highlight their challenges and requirements that must be met using the magnetic nanoparticles to achieve the most effective outcomes. Finally, we conclude this review by providing an insight towards resolving the persisting challenges and the future directions. This review should be an excellent source of information for beginners in this field who are looking for a groundbreaking start but they have been overwhelmed by the volume of literature.

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“…Electromagnetic warming (or “microwave” [139, 140] or “dielectric” [141, 142] warming) and, more recently, magnetic nanoparticle warming [137, 143, 144] (nanowarming) and warming with metal forms [145] have been proposed and studied for faster and more uniform heating of tissue during recovery from the vitrified state.…”

Section: Bioengineering Applicationsmentioning

confidence: 99%

New Approaches to Cryopreservation of Cells, Tissues, and Organs

Taylor¹,

Weegman²,

Baicu³

et al. 2019

Transfus Med Hemother

131

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In this concept article, we outline a variety of new approaches that have been conceived to address some of the remaining challenges for developing improved methods of biopreservation. This recognizes a true renaissance and variety of complimentary, high-potential approaches leveraging inspiration by nature, nanotechnology, the thermodynamics of pressure, and several other key fields. Development of an organ and tissue supply chain that can meet the healthcare demands of the 21st century means overcoming twin challenges of (1) having enough of these lifesaving resources and (2) having the means to store and transport them for a variety of applications. Each has distinct but overlapping logistical limitations affecting transplantation, regenerative medicine, and drug discovery, with challenges shared among major areas of biomedicine including tissue engineering, trauma care, transfusion medicine, and biomedical research. There are several approaches to biopreservation, the optimum choice of which is dictated by the nature and complexity of the tissue and the required length of storage. Short-term hypothermic storage at temperatures a few degrees above the freezing point has provided the basis for nearly all methods of preserving tissues and solid organs that, to date, have proved refractory to cryopreservation techniques successfully developed for single-cell systems. In essence, these short-term techniques have been based on designing solutions for cellular protection against the effects of warm and cold ischemia and basically rely upon the protective effects of reduced temperatures brought about by Arrhenius kinetics of chemical reactions. However, further optimization of such preservation strategies is now seen to be restricted. Long-term preservation calls for much lower temperatures and requires the tissue to withstand the rigors of heat and mass transfer during protocols designed to optimize cooling and warming in the presence of cryoprotective agents. It is now accepted that with current methods of cryopreservation, uncontrolled ice formation in structured tissues and organs at subzero temperatures is the single most critical factor that severely restricts the extent to which tissues can survive procedures involving freezing and thawing. In recent years, this major problem has been effectively circumvented in some tissues by using ice-free cryopreservation techniques based upon vitrification. Nevertheless, despite these promising advances there remain several recognized hurdles to be overcome before deep-subzero cryopreservation, either by classic freezing and thawing or by vitrification, can provide the much-needed means for biobanking complex tissues and organs for extended periods of weeks, months, or even years. In many cases, the approaches outlined here, including new underexplored paradigms of high-subzero preservation, are novel and inspired by mechanisms of freeze tolerance, or freeze avoidance, in nature. Others apply new bioengineering techniques such as nanotechnology, isochoric pressure preserv...

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From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer

Cited by 27 publications

References 154 publications

Aggregation affects optical properties and photothermal heating of gold nanospheres

Aggregation affects optical properties and photothermal heating of gold nanospheres

A Guideline for Effectively Synthesizing and Characterizing Magnetic Nanoparticles for Advancing Nanobiotechnology: A Review

New Approaches to Cryopreservation of Cells, Tissues, and Organs

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