From Normal Flora to Brain Abscesses: A Review of Streptococcus intermedius

Issa, Elio; Salloum, Tamara; Tokajian, Sima

doi:10.3389/fmicb.2020.00826

Cited by 75 publications

(149 citation statements)

References 82 publications

Supporting

Mentioning

135

Contrasting

Order By: Relevance

“…1 The onset of S intermedius brain abscess formation is typically chronic, beginning with tissue damage that precedes bacterial colonization, liquefaction, and pus formation through hyaluronidase activity. 2 Our case presents a previously healthy pediatric patient who presented with sudden syncope and altered mental status, which was ultimately revealed to be due to a massive intracranial abscess caused by S intermedius.…”

Section: Discussionmentioning

confidence: 95%

Mastoiditis Caused by Streptococcus intermedius

Modi¹,

Maniam²,

Bluhm³

et al. 2021

Consultant

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Mastoiditis Caused by Streptococcus intermedius

Modi¹,

Maniam²,

Bluhm³

et al. 2021

Consultant

View full text Add to dashboard Cite

“…[ 13 ] In addition, the most important underlying risk factors for brain abscess caused by S. intermedius are dental manipulation and sinusitis. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Brain abscess of odontogenic origin in patients with malignant tumors: A report of two cases

Shibata

Hashimoto

Okura

et al. 2021

Surgical Neurology International

View full text Add to dashboard Cite

Background: Oral infection and dental manipulations can lead to the development of brain abscesses, a rare but potentially life-threatening condition. Herein, we report patients undergoing cancer treatment who developed brain abscesses of odontogenic origin at our hospital. Case Description: Two patients developed brain abscesses during cancer treatment. Both underwent neurosurgical aspiration, and the causative microorganism was identified as Streptococcus intermedius of the Streptococcus anginosus group, which is a part of the normal bacterial flora in the oral cavity. There was clinical and radiographic evidence of dental infection in one of the patients diagnosed with a brain abscess of odontogenic origin. No infectious foci were found in the other patient during hospitalization for the abscess. However, the patient had undergone extraction of an infected tooth approximately 3 months before admission for the abscess, suggesting origination from an oral infection or dental manipulation. The patients’ cancers rapidly worsened because cancer treatment in both patients was interrupted for several months to treat the brain abscess. Conclusion: Oral infections can cause severe infections, such as brain abscesses, particularly during the treatment of malignant tumors. Improving the oral environment or treating oral infections before initiating treatment for malignant tumors is highly recommended. In addition, the possibility of odontogenic origin should always be considered as a potential etiology of brain abscesses.

show abstract

“…VGS have the tendency to develop brain abscesses and infective endocarditis [ 7 , 8 ]. Our patient did not have evidence of fluid collection on the brain MRI, and echocardiography showed no vegetation or valve disease.…”

Section: Discussionmentioning

confidence: 99%

Viridans Group Streptococcus Meningitis in an Immunocompetent Child: A Case Report

et al. 2021

View full text Add to dashboard Cite

Patient: Female, 14-month-old Final Diagnosis: Viridans group streptococcus meningitis Symptoms: Fever • irritability • vomiting Medication: — Clinical Procedure: — Specialty: Infectious Diseases Objective: Rare disease Background: Viridans group streptococci (VGS) are commensal organisms in humans that are considered contaminants when isolated from culture specimens. However, VGS can be pathogenic when recovered multiple times from blood cultures or when in immunocompromised hosts. VGS are the leading cause of dental abscesses and infective endocarditis in children with underlying congenital heart diseases. They are not commonly involved in meningeal infections, but meningitis due to VGS can be fatal if not treated. The onset is usually preceded by an upper respiratory tract infection or in association with neurological surgical procedures. Case Report: Our patient was a 14-month-old girl with no significant past medical history who presented with fevers and irritability for 2 weeks. A full sepsis workup, including blood, urine, and cerebrospinal fluid (CSF) cultures, was obtained. Culture results were notable for the abundant growth of VGS in the CSF. However, brain imaging and echocardiogram were normal, with no evidence of brain abscesses or cardiac vegetations, respectively. The patient had shown marked clinical improvement after receiving 2 weeks of intravenous ceftriaxone, which was selected based on the VGS susceptibility profile. Conclusions: Bacterial meningitis is one of the most burdensome infectious diseases worldwide, despite improvements in diagnostic methods, management, and national immunization programs. Clinicians should consider VGS in the differential diagnosis of potential infections that can cause meningitis.

show abstract

From Normal Flora to Brain Abscesses: A Review of Streptococcus intermedius

Cited by 75 publications

References 82 publications

Mastoiditis Caused by Streptococcus intermedius

Mastoiditis Caused by Streptococcus intermedius

Brain abscess of odontogenic origin in patients with malignant tumors: A report of two cases

Viridans Group Streptococcus Meningitis in an Immunocompetent Child: A Case Report

Contact Info

Product

Resources

About