From pathogenesis to clinical practice: Emerging medical treatments for endometriosis

Clemenza, Sara; Sorbi, Flavia; Noci, Ivo; Capezzuoli, Tommaso; Turrini, Irene; Carriero, Carlo; Buffi, Nicolò Maria; Fambrini, Massimiliano; Petraglia, Felice

doi:10.1016/j.bpobgyn.2018.01.021

Cited by 51 publications

(46 citation statements)

References 74 publications

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“…Several progestogens administered using different modalities have been treated for endometriosis . LNG‐IUS released 20 μg levonorgestrel every 24 h during a 5‐year period and acted by modifying the hormonal milieu with the goal of inducing atrophy of the ectopic endometrium . Thus, LNG‐IUS could avoid daily drug intake.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of endometriosis has not been definitively established, however, the main pathogenic events were an increased expression of estrogen receptors and of a progesterone resistance in endometriotic tissue. 25 Several progestogens administered using different modalities have been treated for endometriosis. 26 LNG-IUS released 20 μg levonorgestrel every 24 h during a 5-year period and acted by modifying the hormonal milieu with the goal of inducing atrophy of the ectopic endometrium.…”

Section: Discussionmentioning

confidence: 99%

“…26 LNG-IUS released 20 μg levonorgestrel every 24 h during a 5-year period and acted by modifying the hormonal milieu with the goal of inducing atrophy of the ectopic endometrium. 25,26 Thus, LNG- IUS could avoid daily drug intake. LNG-IUS could be one of the available option for postoperative pain relief and preventing recurrence of endomtriosis.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the efficacy of diegnogest and levonorgestrel‐releasing intrauterine system after laparoscopic surgery for endometriosis

Lee

Jung

Song

et al. 2018

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the efficacy of diegnogest and levonorgestrel‐releasing intrauterine system after laparoscopic surgery for endometriosis

Lee

Jung

Song

et al. 2018

J of Obstet and Gynaecol

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“…CB1 agonists are investigated as a possible treatment for endometriosis with contradictory results. While WIN 55,212-2 limited cell proliferation in vitro, methanandamide (5 mg/kg) contributed to development of ectopic lesions in mice [318]. However, modulation of ECS in gynecological disorders has lot of limitations.…”

Section: Reproductive Systemmentioning

confidence: 99%

A Guide to Targeting the Endocannabinoid System in Drug Design

Stasiulewicz

Znajdek

Grudzień

et al. 2020

IJMS

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The endocannabinoid system (ECS) is one of the most crucial systems in the human organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of physiological processes, including nociception, mood regulation, cognitive functions, neurogenesis and neuroprotection, appetite, lipid metabolism, as well as cell growth and proliferation. Thus, ECS proteins, including cannabinoid receptors and their endogenous ligands’ synthesizing and degrading enzymes, are promising therapeutic targets. Their modulation has been employed in or extensively studied as a treatment of multiple diseases. However, due to a complex nature of ECS and its crosstalk with other biological systems, the development of novel drugs turned out to be a challenging task. In this review, we summarize potential therapeutic applications for ECS-targeting drugs, especially focusing on promising synthetic compounds and preclinical studies. We put emphasis on modulation of specific proteins of ECS in different pathophysiological areas. In addition, we stress possible difficulties and risks and highlight proposed solutions. By presenting this review, we point out information pivotal in the spotlight of ECS-targeting drug design, as well as provide an overview of the current state of knowledge on ECS-related pharmacodynamics and show possible directions for needed research.

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“…Elagolix has hypoestrogenic adverse effects, as with the other GnRH analogs, and further studies are necessary to compare elagolix to existing therapies and evaluate the need for addback therapy. 38 Currently, there are several other investigational GnRH analogs in preclinical and clinical trials, under further development. 28…”

Section: Gonadotropin-releasing Hormone Analogsmentioning

confidence: 99%

Endometriosis and Female Pelvic Pain

Kim

Han

2018

Semin Reprod Med

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Endometriosis is a nonmalignant gynecologic disorder that can have a significant impact on a woman's quality of life with pelvic pain and possible lasting effects on one's fertility. Symptoms, when present, can be severe and affect many organ systems including the gastrointestinal and urinary systems. Other etiologies of pelvic pain must be ruled out and/or need to be addressed concurrently for optimal patient care. There are numerous medical and surgical treatment options available that have been shown to be beneficial for endometriosis-related pelvic pain. Recurrence is common when medications are discontinued and even after surgical therapy. Ultimately, the treatment approach will be dependent on the needs of the patient, taking into consideration the patient's desire for fertility, symptoms, past treatment, and patient preferences.

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From pathogenesis to clinical practice: Emerging medical treatments for endometriosis

Cited by 51 publications

References 74 publications

Comparison of the efficacy of diegnogest and levonorgestrel‐releasing intrauterine system after laparoscopic surgery for endometriosis

Comparison of the efficacy of diegnogest and levonorgestrel‐releasing intrauterine system after laparoscopic surgery for endometriosis

A Guide to Targeting the Endocannabinoid System in Drug Design

Endometriosis and Female Pelvic Pain

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