From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane

Mizuno, Akira; Matsui, Kouhei; Shuto, Satoshi

doi:10.1002/chem.201702119

Cited by 52 publications

(34 citation statements)

References 133 publications

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“…Methods for combatting biofilms using natural peptides seem promising, but their therapeutic relevance is limited by inherently low stability and availability (Kang et al, 2014 ). Therefore, antibiofilm peptidomimetics are being studied as way to mimic natural peptides while avoiding their drawbacks (Mizuno et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Promising Antibiofilm Activity of Peptidomimetics

et al. 2018

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Pathogenic biofilms are a global health care concern, as they can cause extensive antibiotic resistance, morbidity, mortality, and thereby substantial economic loss. Scientific efforts have been made over the past few decades, but so far there is no effective treatment targeting the bacteria in biofilms. Antimicrobial peptidomimetics have been proposed as promising potential anti-biofilm agents. Indeed, these structurally enhanced molecules can mimic the action of peptides but are not susceptible to proteolysis or immunogenicity, the characteristic limitations of natural peptides. Here, we provide insights into antibiofilm peptidomimetic strategies and molecular targets, and discuss the design of two major peptidomimetics classes: AApeptides (N-acylated-N-aminoethyl-substituted peptides) and peptoids (N-substituted glycine units). In particular, we present details of their structural diversity and discuss the possible improvements that can be implemented in order to develop antibiofilm drug alternatives.

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Section: Discussionmentioning

confidence: 99%

Promising Antibiofilm Activity of Peptidomimetics

et al. 2018

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“…For example, poly(L-lactic acid) (PLLA) nanofibers coated with LN enhanced the attachment and proliferation of PC12 cells vs. unmodified fibers ( Figure 1B) (Koh et al, 2008). In some cases, protein fragments containing the binding domains or peptidomimetica are used for surface functionalization instead of the whole protein (Mizuno et al, 2017). Short peptidomimetics are easier to control and manipulate in comparison to the full protein for biomaterial applications.…”

Section: Biomaterials That Support Neuronal Cell Adhesionmentioning

confidence: 99%

Microenvironments Designed to Support Growth and Function of Neuronal Cells

2018

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Strategies for neural tissue repair heavily depend on our ability to temporally reconstruct the natural cellular microenvironment of neural cells. Biomaterials play a fundamental role in this context, as they provide the mechanical support for cells to attach and migrate to the injury site, as well as fundamental signals for differentiation. This review describes how different cellular processes (attachment, proliferation, and (directional) migration and differentiation) have been supported by different material parameters, in vitro and in vivo. Although incipient guidelines for biomaterial design become visible, literature in the field remains rather phenomenological. As in other fields of tissue regeneration, progress will depend on more systematic studies on cell-materials response, better understanding on how cells behave and understand signals in their natural milieu from neurobiology studies, and the translation of this knowledge into engineered microenvironments for clinical use.

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“…Peptides have been known to have a crucial function in human physiology-act as hormones, neurotransmitters, growth factors, ion channel ligands, or anti-infective agents. Most of the discovered peptides have undesirable properties for drug application due to their low metabolic stability, low oral activity, rapid excretion, and low cell-membrane permeability (Mizuno et al 2017). Therefore, structural and functional modification of the bioactive peptide has been established to improve the pharmacokinetics drawbacks of the peptide, one of which is through the cyclization method.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Peptides Targeting DNA Methyltransferase 1 (DNMT-1) for Breast Cancer Treatment

Saragih

Stephanie

Alkaff

et al. 2020

Rev. Bras. Farmacogn.

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Epigenetic alteration shows an essential role in the process of breast cancer cell proliferation and propagation. DNA methyltransferase (DNMT) is responsible for DNA methylation, resulted in the epigenetic silencing of multiple genes. Hence, inhibiting DNMT-1 is a promising way to block uncontrolled DNA methylation. This study aimed to retrieve a potential peptide compound as DNMT-1 inhibitor due to its desirable properties as drug candidate through virtual screening and molecular docking simulation. A total of 51,957 peptide ligands from PubChem database underwent computational pharmacological screening to eliminate compounds with undesired characteristics. Molecular docking simulation was done with generated pharmacophore features, and the potential ligands with good ΔG binding, RMSD value, and molecular interaction were cyclized to increase the bioavailability of the peptides. Cyclic peptide ligands were tested for its interaction with DNMT-1 protein and ADME-Tox properties. From these steps, three cyclic peptide ligands showed desirable characteristics as a new drug candidate for the DNMT1 inhibitor.

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From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane

Cited by 52 publications

References 133 publications

Promising Antibiofilm Activity of Peptidomimetics

Promising Antibiofilm Activity of Peptidomimetics

Microenvironments Designed to Support Growth and Function of Neuronal Cells

Identification of Novel Peptides Targeting DNA Methyltransferase 1 (DNMT-1) for Breast Cancer Treatment

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