From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM

Oubré, Alondra; Carlson, Thomas J.; King, Steven R.; Reaven, Gerald M.

doi:10.1007/s001250050724

Cited by 188 publications

(110 citation statements)

References 17 publications

(16 reference statements)

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“…Hence, plants have been suggested as a rich, as yet unexplored source of potentially useful antidiabetic drugs. However, only a few have been subjected to detailed scientific investigation due to a lack of mechanism-based available in vitro assays (Oubre et al, 1997;Fabricant & Farnsworth, 2001;Habeck, 2003). Fenugreek (Trigonella foenum-graecum L., Leguminosae), one of the oldest medicinal plants, is of Mediterranean origin and cultivated worldwide.…”

Section: Introductionmentioning

confidence: 99%

The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway

Vijayakumar

Singh

Chhipa

et al. 2005

British J Pharmacology

134

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1 The in vivo hypoglycaemic activity of a dialysed fenugreek seed extract (FSE) was studied in alloxan (AXN)-induced diabetic mice and found to be comparable to that of insulin (1.5 U kg À1). FSE also improved intraperitoneal glucose tolerance in normal mice. 2 The mechanism by which FSE attenuated hyperglycaemia was investigated in vitro. FSE stimulated glucose uptake in CHO-HIRc-mycGLUT4eGFP cells in a dose-dependent manner. This effect was shown to be mediated by the translocation of glucose transporter 4 (GLUT4) from the intracellular space to the plasma membrane. 3 These effects of FSE on GLUT4 translocation and glucose uptake were inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, and bisindolylmaleimide 1, a protein kinase C (PKC)-specific inhibitor. 4 In vitro phosphorylation analysis revealed that, like insulin, FSE also induces tyrosine phosphorylation of a number of proteins including the insulin receptor, insulin receptor substrate 1 and p85 subunit of PI3-K, in both 3T3-L1 adipocytes and human hepatoma cells, HepG2. However, unlike insulin, FSE had no effect on protein kinase B (Akt) activation. 5 These results suggest that in vivo the hypoglycaemic effect of FSE is mediated, at least in part, by the activation of an insulin signalling pathway in adipocytes and liver cells.

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Section: Introductionmentioning

confidence: 99%

The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway

Vijayakumar

Singh

Chhipa

et al. 2005

British J Pharmacology

134

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“…Some of them are being used in ~raditional systems of medicine from hundreds of years in many countries of the world. Till today metformin is the only ethical drug approved for the treatment of NIDDM patients which is derived from a medicinal plant Galega officinalis historically used for treatment of diabetes in medieval Europe (7). There are many antidiabetic plants which might provide useful sources for the development of drugs which can be used in the treatment of diabetes mellitus.…”

mentioning

confidence: 99%

Medicinal plants for treatment of diabetes mellitus

Shukia

Sharma

Puri

et al. 2000

Indian J Clin Biochem

120

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“…Many pharmaceuticals conventional drugs have natural plant origins. An example is metformin which is obtained from Galega officinalis, which is a common folkloric remedy for diabetes mellitus [12,13].…”

Section: Introductionmentioning

confidence: 99%

In-Vivo Oral and Intraperitoneal Administration of Extract from Vernonia lasiopus

Lk¹,

Njagi²,

Orinda³

2018

Med Aromat Plants

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Diabetes mellitus in Kenya is a major health concern as it is known to result in mobility, mortality, and long-term complications. Conventional drugs used in the management of diabetes mellitus are unavailable, expensive, and have numerous side effects. Vernonia lasiopus plant has a folkloric usage in diabetes mellitus management though its efficacy needs to be evaluated scientifically. This study therefore aimed at establishing in vivo antihyperglycemic effect of aqueous leaf extract from Vernonia lasiopus in alloxan-induced diabetic male albino mice. Eight groups of mice each group having five mice were used in the study. The plasma sugar lowering effect was monitored after intraperitoneal and oral administration of Vernonia lasiopus extract at doses of 25, 48.4, 93.5, 180.9 and 350 mg/kg body weight. The treatment effects of extracts were compared with the positive controls (insulin and glibenclamide treated for intraperitoneal and oral routes respectively). Standard procedures were used to determine the phytochemicals present in the extracts. ANOVA and post-ANOVA was used to analyze the data collected. The results of the study showed that the aqueous leaves extract at all the five doses administered demonstrated antihyperglycemic effect in a dose independent manner. The phytochemical results showed the presence of phenols, tannins, alkaloids, and flavonoids. The antidiabetic effects shown by the plant extract could be due to the phytochemicals present. Vernonia lasiopus aqueous leaves extract has antidiabetic effects and the study therefore recommends its folkloric use in management of diabetes mellitus.

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From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM

Cited by 188 publications

References 17 publications

The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway

The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway

Medicinal plants for treatment of diabetes mellitus

In-Vivo Oral and Intraperitoneal Administration of Extract from Vernonia lasiopus

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