Sustainability, chemical safety, and circular economy represent holistic frameworks that support chemical synthesis, design, manufacturing, use, reuse, recycling, and disposal to create a closed-loop economic production system. Also, these frameworks target minimizing waste generation, energy consumption, and fresh raw material needs, maximizing resource efficiency, and economic, social, and environmental benefits. Therefore, designing a safer economy for chemicals includes the contribution of all chemical life cycle stages, starting from utilizing safer renewable feedstocks, developing safer chemical products, implementing sustainable chemical manufacturing systems, effective regulatory foundations, and non-destructive end-of-life management systems.