From Pregnancy to Preeclampsia: A Key Role for Estrogens

Berkane, Nadia; Lière, Philippe; Oudinet, Jean–Paul; Hertig, Alexandre; Lefèvre, Guillaume; Pluchino, Nicola; Schumacher, Michaël; Chabbert-Buffet, Nathalie

doi:10.1210/er.2016-1065

Cited by 167 publications

(133 citation statements)

References 262 publications

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“…The first is that oestrogens promote placental angiogenesis by enhancing VEGF gene expression and uterine artery vasodilation by increasing nitric oxide (NO) production, key events ensuring a healthy pregnancy outcome [23]. A further primary line of evidence was provided by the detection of reduced catechol-O -methyltransferase (COMT) enzyme activity in PE placentae, and that mice lacking this enzyme exhibit PE-like symptoms [23].…”

Section: Could a Hormone Imbalance Contribute To The Development Of Pmentioning

confidence: 99%

“…Oestrogen exists in a number of forms, including oestrone (E1), 17-β2-oestradiol (E2), oestriol (E3) and oestetriol (E4) [20][21][22][23]. Akin to E3, the concentrations of P4 increase from the beginning of the second trimester, peaking immediately prior to parturition [20][21][22][23]. E4 is unique by being produced by the fetal liver.…”

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

“…An interesting interplay occurs in the menstrual cycle between E2 and P4, in that E2 levels peak in the follicular phase prior to ovulation, while P4 concentrations are greatest in the luteal phase, where it would assist with implantation of a fertilized zygote [20][21][22][23].…”

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

“…The steroid sex hormones play a crucial role in optimizing the milieu of the female reproductive tract (FRT) to ensure conception, implantation, maintenance and growth of the fetus throughout gestation [20][21][22][23]. Oestrogen exists in a number of forms, including oestrone (E1), 17-β2-oestradiol (E2), oestriol (E3) and oestetriol (E4) [20][21][22][23]. In reproductively active humans the major form is E2, while in pregnancy E3 is the predominant form, being largely produced by the placenta.…”

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

“…P4 is also produced by the placenta during pregnancy. Akin to E3, the concentrations of P4 increase from the beginning of the second trimester, peaking immediately prior to parturition [20][21][22][23].…”

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

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The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines

Hahn

Harmatz

Vokálová

et al. 2019

Clinical and Experimental Immunology

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Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrating this regulation are cyclical steroid sex hormones present during the menstrual cycle and pregnancy. This review describes the role of sex hormones in regulating directly or indirectly the functionality of neutrophils, the role of neutrophils during fertilization and pregnancy and in controlling viral, fungal and bacterial infection. This review also discusses the consequence of overt neutrophil activation in pregnancy pathologies.Our intention in this review is to highlight new observations made during discrete stages of the reproductive cycle, focusing particularly on the role of sex hormones and cytokines in modulating neutrophil activity and their potential dysregulation in pathology.

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Section: Could a Hormone Imbalance Contribute To The Development Of Pmentioning

confidence: 99%

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

Section: Hormone Regulation Of the Reproductive Cycle -Introducing Thmentioning

confidence: 99%

See 3 more Smart Citations

The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines

Hahn

Harmatz

Vokálová

et al. 2019

Clinical and Experimental Immunology

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Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling

Chaudhari

Cushen

Osikoya

et al. 2018

Comprehensive Physiology

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Epidemiological studies demonstrate disparities between men and women in cardiovascular disease prevalence, clinical symptoms, treatments, and outcomes. Enrollment of women in clinical trials is lower than men, and experimental studies investigating molecular mechanisms and efficacy of certain therapeutics in cardiovascular disease have been primarily conducted in male animals. These practices bias data interpretation and limit the implication of research findings in female clinical populations. This review will focus on the biological origins of sex differences in cardiovascular physiology, health, and disease, with an emphasis on the sex hormones, estrogen and testosterone. First, we will briefly discuss epidemiological evidence of sex disparities in cardiovascular disease prevalence and clinical manifestation. Second, we will describe studies suggesting sexual dimorphism in normal cardiovascular function from fetal life to older age. Third, we will summarize and critically discuss the current literature regarding the molecular mechanisms underlying the effects of estrogens and androgens on cardiac and vascular physiology and the contribution of these hormones to sex differences in cardiovascular disease. Fourth, we will present cardiovascular disease risk factors that are positively associated with the female sex, and thus, contributing to increased cardiovascular risk in women. We conclude that inclusion of both men and women in the investigation of the role of estrogens and androgens in cardiovascular physiology will advance our understanding of the mechanisms underlying sex differences in cardiovascular disease. In addition, investigating the role of sex‐specific factors in the development of cardiovascular disease will reduce sex and gender disparities in the treatment and diagnosis of cardiovascular disease. © 2019 American Physiological Society. Compr Physiol 9:375‐411, 2019.

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Effects of dibenzothiophene, a sulfur‐containing heterocyclic aromatic hydrocarbon, and its alkylated congener, 2,4,7‐trimethyldibenzothiophene, on placental trophoblast cell function

Raez-Villanueva

Perono

Jamshed

et al. 2020

J of Applied Toxicology

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Worldwide demand for petroleum products has resulted in increased oil and gas activities in many countries. Conventional and unconventional oil and gas extraction, production, and transport lead to increased levels of petroleum‐derived polycyclic aromatic hydrocarbons (PAHs) in the environment. PAH exposure has profound effects on reproduction by affecting pathways involved in placental trophoblast cell function and impairing normal placental development and function—key contributors to reproductive success. However, other components found in petroleum and wastewaters from oil and gas extraction, including the sulfur‐containing heterocyclic aromatic compounds such as dibenzothiophene (DBT) and its alkylated derivatives, may also impact reproductive success. The goal of this study was to examine the effect of exposure to DBT, a compound commonly detected in the environment, and one of its alkylated analogues, 2,4,7‐trimethyldibenzothiophene (2,4,7‐DBT), on steroidogenic and angiogenic pathways critical for mammalian development in placental trophoblast cells (HTR‐8/SVneo cells). 2,4,7‐DBT but not DBT increased estradiol output in association with increased tube‐like formation (surrogate for angiogenesis). These changes in angiogenesis did not appear to be related to altered expression of the key placental angiogenic gene targets (ANGPTL4, VEGFA, and PGF). Neither compound showed a concentration related effect on progesterone synthesis or its receptor expression. Our results suggest that 2,4,7‐DBT can disrupt key pathways important for placental trophoblast function and highlight the importance of determining the impact of exposure to both parent and alkylated compounds. Further, these data suggest that exposure to sulfur‐containing heterocyclic aromatic compounds may lead to placental dysfunction and impact reproductive success at environmentally relevant levels.

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From Pregnancy to Preeclampsia: A Key Role for Estrogens

Cited by 167 publications

References 262 publications

The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines

The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines

Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling

Effects of dibenzothiophene, a sulfur‐containing heterocyclic aromatic hydrocarbon, and its alkylated congener, 2,4,7‐trimethyldibenzothiophene, on placental trophoblast cell function

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