From prolactin cell to prolactinoma: implications of ontogenic mechanisms in diagnosis and management

Velkeniers, B.

doi:10.1677/erc.0.0050027

Cited by 3 publications

(2 citation statements)

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“…They are characterized by high invasiveness and aggression, with impressive extrasellar expansion [3,4], and by the production of very high serum levels of prolactin (usually more than 1,000 ng/ml). They are also more often associated with other endocrine tumors, such as parathyroid adenomas or pancreatic endocrine tumors, as part of the familial syndrome of multiple endocrine neoplasia type 1 [5]. Symptoms at diagnosis are similar to those in men with macroprolactinomas [6].…”

Section: Introductionmentioning

confidence: 96%

Unusual clinical presentations of giant prolactinomas

Grozinsky‐Glasberg

Shimon

2008

Pituitary

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Giant prolactinomas are rare pituitary tumors which have scarcely been reported in the literature. We describe three men with unusual presenting features of prolactin-secreting giant pituitary adenomas: prolonged and increasingly disturbing intolerance to light and noise; strange behavior and mood disturbances; and rhinorrhea followed by a finding of cerebrospinal fluid leakage. Treatment with dopamine agonist alleviated all symptoms, with concomitant suppression of plasma prolactin levels and a significant reduction in tumor mass. These cases emphasize the importance of considering unusual symptoms in the differential diagnosis of giant prolactinomas and the effectiveness of medical treatment.

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Section: Introductionmentioning

confidence: 96%

Unusual clinical presentations of giant prolactinomas

Grozinsky‐Glasberg

Shimon

2008

Pituitary

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“…Si bien se han adoptado varias definiciones, en general, la que tiene mayor consenso es la que contempla dos aspectos: 1) la imposibilidad de restaurar niveles normales de prolactina, y 2) la imposiblidad de conseguir una reducción mayor del 50% en el tamaño del tumor. Algunos pacientes responden a ia terapia dopaminérgica con la normalización de los niveles de prolactina sin reducción sustancial del tamaño tumoral, y otros reducen el tamaño sin lograr normalizar su prolactinemia (Velkeniers & Hooghe-Peters 1998).…”

Section: Definición De Pacientes Resistentes a Agonistas Dopaminérgicosunclassified

Tumorogénesis hipofisaria: factores de crecimiento y angiogénicos en modelos experimentales y adenomas hipofisarios humanos

Socolovschi¹

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El objetivo general de la tesis es estudiar la génesis y regulación de los prolactinomas. Para ello nos valimos de los ratones knockout para el receptor de dopamina D2, que desarrollan una hiperplasia de lactotropos a los 8 meses y posteriormente un adenoma verdadero. Nos focalizamos en el estudio de factores de crecimiento y angiogénicos; VEGF, FGF-2 y PTTG y aplicamos también una terapia antiangiogénica en hipófisis. Se estudiaron además, los factores mencionados en adenomas hipofisarios humanos.

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Clinical Impact of the Current WHO Classification of Pituitary Adenomas

et al. 2016

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WHO classifications should be used for comparing the results from different groups of pathologist and clinicians by standardized histopathological methods. Our present report describes the important parameters of pituitary adenoma pathology as demand of the WHO classification for correlation to endocrine data and prognosis. The combination of HE stain based structures with immunostainings for pituitary hormones allows subclassification of adenomas as the best method not only for correlations to clinical hyperfunctions but also for statements to the sensitivity of drug therapies (somatostatin analogs, dopamine agonists). GH-, PRL- and ACTH-secreting pituitary adenomas are further classified based on the size and number of their secretory granules by electron microscopy, or as is mostly the case nowadays by cytokeratin staining pattern, into densely and sparsely granulated. Granulation pattern may be considered for the prediction of treatment response in patients with GH-secreting adenomas, since the sparsely granulated subtype was shown to be less responsive to somatostatin analog treatment. For prognosis, it is important to identify aggressive adenomas by measurements of the Ki-67 index, of the number of mitoses, and of nuclear expression of p53. Among the criteria for atypical adenomas, high Ki-67 labeling index and invasive character are the most important adverse prognostic factors. Promising molecular markers have been identified that might supplement the currently used proliferation parameters. For defining atypical adenomas in a future histopathological classification system, we propose to provide the proliferative potential and the invasive character separately.

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From prolactin cell to prolactinoma: implications of ontogenic mechanisms in diagnosis and management

Cited by 3 publications

References 100 publications

Unusual clinical presentations of giant prolactinomas

Unusual clinical presentations of giant prolactinomas

Tumorogénesis hipofisaria: factores de crecimiento y angiogénicos en modelos experimentales y adenomas hipofisarios humanos

Clinical Impact of the Current WHO Classification of Pituitary Adenomas

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