The geography of ageing is addressed in this article by providing new empirical evidence about the significant role of daily activities on the perceptions of isolation and loneliness. The developed model of socio-spatial isolation is based on data from time-space diaries and questionnaires completed by older adults living in three cities in the Czech Republic. The study suggests that socio-spatial isolation is a multicomponent (consisting of passivity, isolation and loneliness components), place-dependent and gendered issue. The passivity is significantly associated with the income and leisure sport activities. The isolation can be well predicted by the age, gender and education, and the frequency of work and specific leisure activities, which are constrained by health conditions, financial opportunities and spatial mobility. Particularly trips to nature, sport activities, cultural events, get together with friends, and visits to restaurants have a positive effect on reducing isolation. Women, particularly those who raised more children, more likely feel lonely in old age when family contacts are reduced. Visits to restaurants, shopping malls and cultural events have a positive effect on reducing loneliness. A constrained mobility and higher time consumption for necessary activities also proved to be an age-related and gendered problem. In this respect, policy interventions should seek to improve flexible work opportunities, the digital skills of older people, and the accessibility and safety of public transport with regard to perceived constraints, which is gaining in importance in the Covid-19 era.