From simple amphiphilic to surfactant behavior: Analysis of 1H NMR chemical shift variations

Enhanced solubility of quercetin by forming composite particles with transglycosylated materials

“…This solubility enhancement was attributed to the incorporation of hydrophobic compounds into the self-associated structure of transglycosylated compound. Stevia-G showed weak surface activity in distilled water (52.5 mN/m), and its critical aggregation concentration (CAC), defined as the concentration of solute above which aggregation form (Luchetti, 2000;Andrade-Dias et al, 2007;Singh and Kumar, 2007;Dong et al, 2010), and the number of molecules consists of the aggregation structure were estimated to be 16 mg/mL and 15, respectively. The aggregation number means the number of molecules consists of the aggregation structure.…”

Effect of cyclodextrins on the reactivity of fenitrothion

“…The fact that two separate signals are observed indicates that the exchange is slow on the NMR timescale. [19][20][21] Since both, the aromatic protons and those of the OMe of the phosphate group showed displacement with respect to the free substrate, the pesticide in solution must be included in a way that the aromatic moiety and the phosphate group are influenced by the host. We carried out ROESY experiments in order to get more information about the mode of inclusion but the signals were not clearly resolved.…”

NMR investigation of a novel excipient, α‐glucosylhesperidin, as a suitable solubilizing agent for poorly water‐soluble drugs

“…Figure 3 shows the dependence of the 1 H chemical shifts on concentration variations for some key Hsp‐G signals that were typically affected by the aggregation. The NMR chemical shift values corresponding to different nuclei in molecular units can be used to detect self‐aggregation behavior, for example, micellization, has been previously documented 23,26. This method could also apply to the investigation of large molecular weight polymer micelles 16.…”

“…Above the CMC, δ obs was the weighted average of the monomer and micelle chemical shifts, based on the assumption that the exchange of monomers and micelles in the solution is comparatively fast on the NMR time scale. If the monomer concentration was constant above the CMC, the observed chemical shift could be described as follows using the mass‐action law model23,26,27: …”