2018
DOI: 10.1002/hbm.24314
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From simultaneous to synergistic MR‐PET brain imaging: A review of hybrid MR‐PET imaging methodologies

Abstract: Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simultaneous imaging and the potential for new diagnostic and research capability. This article reviews state-of-the-art MR-PET hardware and software, and discusses future developments focusing on neuro… Show more

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Cited by 70 publications
(62 citation statements)
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References 176 publications
(245 reference statements)
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“…Fusion information of MR and PET provides advantages over PET and computed tomography (CT) in neurological applications, as overlaying MR and PET image supplies improved diagnostic information in characterization of many conditions [13]. Beyond image fusion, MR offers a library of multiparametric imaging information from morphology, function to even metabolism that cannot be obtained from CT. MR has also an excellent sensitivity in capturing the small changes in brain structure and function [14]. PET on the other hand, offers a high specificity and a wide quality of radiotracers applicable for investigation of numerous molecular targets [14].…”
Section: Introductionmentioning
confidence: 99%
“…Fusion information of MR and PET provides advantages over PET and computed tomography (CT) in neurological applications, as overlaying MR and PET image supplies improved diagnostic information in characterization of many conditions [13]. Beyond image fusion, MR offers a library of multiparametric imaging information from morphology, function to even metabolism that cannot be obtained from CT. MR has also an excellent sensitivity in capturing the small changes in brain structure and function [14]. PET on the other hand, offers a high specificity and a wide quality of radiotracers applicable for investigation of numerous molecular targets [14].…”
Section: Introductionmentioning
confidence: 99%
“…These results suggested that FDG-PET measures a more widely distributed neuronal network than BOLD-fMRI, and potentially enables the identification of task-relevant secondary regions that are not detected by BOLD. (18)), together with the improved PET signal detection of dual modality scanners (15) has now made it possible to study dynamic changes in glucose metabolism simultaneously with dynamic changes in blood oxygenation. The method described as 'functional' FDG-PET (FDG-fPET) involves the radiotracer administered as a constant infusion over the course of the entire PET scan (~90-mins; (19)).…”
Section: Introductionmentioning
confidence: 99%
“…The task was presented in an embedded block design (Jamadar et al, 2018). We have previously shown that 8…”
Section: Participants and Task Designmentioning
confidence: 99%
“…In the past 5 years, the development and wider accessibility of clinical-grade simultaneous MRI-PET scanners 36 has sparked renewed research interest in FDG-PET imaging (Chen et al, 2018). With these developments, 37…”
Section: Introductionmentioning
confidence: 99%