From soil to brain: Zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism

Lambein, Fernand; Haque, Rabiul; Khan, Jehangir K.; Kebede, Naod; Kuo, Yao‐Haur

doi:10.1016/0041-0101(94)90298-4

Cited by 65 publications

(39 citation statements)

References 14 publications

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“…An electrolyte imbalance may be fur ther aggravated by a diarrheal episode or ex cessive perspiration by laborers in the humid atmosphere of Bangladesh. A link between zinc deficiency and susceptibility to the toxic effects of (3-ODAP has recently been proposed [26], and this might be corroborated by our findings, although more chemical analyses are needed to confirm such a link.…”

Section: Lathyrism In Northwestern Districts Of Bangladeshsupporting

confidence: 77%

See 1 more Smart Citation

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

Haque¹,

Hossain²,

Wouters

et al. 1996

Neuroepidemiology

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Two northwestern districts of Bangladesh with a population of 629,752 were surveyed from June 1991 to March 1993 to detect and follow up lathyrism patients. Out of 2,567 neurological patients, 882 were diagnosed as having lathyrism, giving a prevalence rate of 14.0/10,000. This prevalence was higher among young males: only 12.9% of the patients were female, and only 19.3% of the patients were over 30 years of age at onset of the disease. The average family size was 4.6 members. In the surveyed area, 730 families were evaluated: 622 families had only 1 affected member, and 108 families had 2–8 affected members. Most of the patients were working, while only 4% were not. The majority of the patients had a very low intake of animal protein. A few cases of human T-lymphotropic virus infection and osteolathyrism were found during this study.

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Section: Lathyrism In Northwestern Districts Of Bangladeshsupporting

confidence: 77%

“…Also the availability to the plant of micronutrients like zinc may play a role. The recently proposed role of p-ODAP in the plant as a carrier molecule for zinc ions [26] might explain local variations in toxicity of the seeds and hence the erratic occurrence of neurolathyrism.…”

Section: Lathyrism In Northwestern Districts Of Bangladeshmentioning

confidence: 99%

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

Haque¹,

Hossain²,

Wouters

et al. 1996

Neuroepidemiology

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“…However, inadequate intake of zinc rather than low bioavailability might be the main risk factor for the zinc deficiency in pregnant women from the study area. High prevalence of zinc deficiency in the present study might be also partially explained by low zinc content of Ethiopian soil, as crops grown locally will have low zinc concentration and households who depend entirely on locally grown crops will be at risk of inadequate zinc intake [41,44,45].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of zinc deficiency and its association with dietary, serum albumin and intestinal parasitic infection among pregnant women attending antenatal care at the University of Gondar Hospital, Gondar, Northwest Ethiopia

et al. 2015

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Prevalence of zinc deficiency and its association with dietary, serum albumin and intestinal parasitic infection among pregnant women attending antenatal care at the University of Gondar Hospital, Gondar, Northwest Ethiopia Conclusion: Zinc deficiency is of public health concern in the study area. To combat the problems, nutrition education to increase knowledge as well as practices concerning the consumption of zinc rich foods and optimal dietary diversity, use of home based phytate reduction techniques and agricultural based approaches should be considered.

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“…ODAP is mainly controlled by genetic factors and lesser by environment (Hanbury et al, 1999). Among abiotic factors, particularly drought results in increased ODAP content (Lambein et al, 1994, Cocks et al, 2000. In our study, ODAP content of grass pea seed exhibited a different trend (Table 3 and 4).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Turkish grass pea (Lathyrus sativus L.) collections for it agronomic characters with a special reference to ODAP content

Başaran

Mut

Gülümser

et al. 2016

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Fifty-two grass pea (Lathyrus sativus L.) genotypes were investigated in terms of agronomic performance, protein and ODAP (b-N-oxalyl-l-diamino-propionic acid) content under semi-arid conditions of Inner Anatolia during 2013 and 2014. High variation was observed among genotypes, especially for seed yield and ODAP content. Seed yield ranged from 1142.4 kg/ha up to 2046.4 kg/ha with a mean of 1521.1 kg/ha, ODAP content in seed varied from 2.62 mg/g up to 5.59 mg/ g with an average of 3.85 mg per g and seed protein ratio was between 26.77% and 30.20% over the genotypes and years. A significant and negative correlation of ODAP was noted with seed yield (r = -0.38). This association is very encouraging for breeders to improve new varieties having high seed yield and low ODAP content. The results from this study indicated that ten grass pea genotypes consisting two ICARDA lines and eight landraces from Turkey recorded superior with low ODAP content and and high seed yield (changed between 1680.9 kg/ha and 2046.4 kg/ha). So, these may be potential candidates for new varieties.

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From soil to brain: Zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism

Cited by 65 publications

References 14 publications

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

Epidemiological Study of Lathyrism in Northwestern Districts of Bangladesh

Prevalence of zinc deficiency and its association with dietary, serum albumin and intestinal parasitic infection among pregnant women attending antenatal care at the University of Gondar Hospital, Gondar, Northwest Ethiopia

Evaluation of Turkish grass pea (Lathyrus sativus L.) collections for it agronomic characters with a special reference to ODAP content

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