From state dissociation to status dissociatus

Antelmi, Elena; Ferri, Raffaele; Iranzo, Álex; Arnulf, Isabelle; Dauvilliers, Yves; Bhatia, Kailash P.; Liguori, Rocco; Schenck, Carlos H.; Plazzi, Giuseppe

doi:10.1016/j.smrv.2015.07.003

Cited by 58 publications

(37 citation statements)

References 91 publications

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“…Eighteen cases had mesial temporal lobe lesions, and two had basal ganglion lesions. 18 F-FDG PET/CTs were available for 17 patients. Among these, 82.4% patients demonstrated an abnormal metabolic pattern involving medial temporal lobes (n = 12), basal ganglia (n = 11), cortex (n = 2), and thalamus (n = 1).…”

Section: Resultsmentioning

confidence: 99%

“…Dream enactment behavior was defined as nocturnal vocalizations and limbs or trunk movements with dream ideation reported by a bed partner. Status dissociatus (SD) was reported as a polysomnographic trait, which was characterized by (i) lack of the conventional features of non-REM (NREM) sleep with the disappearance of spindle and delta activities; and (ii) unstable REM sleep appearing in short recurrent episodes, isolated, or mixed with NREM potentials (18). The most severe type of SD, associated with nearly continuous motor overactivation and peculiar dream-like behavior, was known as agrypnia excitata.…”

Section: Sleep Assessmentsmentioning

confidence: 99%

“…The most severe type of SD, associated with nearly continuous motor overactivation and peculiar dream-like behavior, was known as agrypnia excitata. Agrypnia excitata had been reported in Morvan's syndrome, familial insomnia, and alcohol withdrawal syndrome (18,19). Patients who had difficulty in initiating sleep, difficulty maintaining sleep, waking up too early, or TST of <360 min resulting in daytime sleep impairment were considered to have insomnia.…”

Section: Sleep Assessmentsmentioning

confidence: 99%

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Sleep Disorders in Leucine-Rich Glioma-Inactivated Protein 1 and Contactin Protein-Like 2 Antibody-Associated Diseases

et al. 2020

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Objective: Sleep disorders are common in voltage-gated potassium channel complex antibody (VGKC-Ab) diseases. The aim was to investigate the sleep disturbances and polysomnography (PSG) characteristics in patients with VGKC-Ab-associated diseases. Methods: Twenty-seven patients with leucine-rich glioma-inactivated protein 1 antibody (LGI1-Ab) encephalitis, seven patients with contactin protein-like 2 antibody (Caspr2-Ab)-associated diseases, and 14 healthy controls with at least one PSG or actigraphy recording were recruited at Peking Union Medical College Hospital from January 2014 to July 2019. Results: Sleep disorders including insomnia, hypersomnia, rapid eye movement (REM) sleep behavior disorder (RBD), periodic limb movements in sleep (PLMS), agrypnia excitata, and obstructive sleep apnea syndrome were observed. Twenty-one PSG recordings from patients with LGI1-Ab encephalitis demonstrated a decrease in total sleep time (TST) (median 365.5, range 184.5-495.5 min), sleep efficiency (70.0%, 47-92%), N3 sleep (9.7%, 0-32.9%), and REM sleep (9.9%, 0.4-27.9%). Of five patients with Caspr2-Ab-associated diseases, TST was found to be 329.5 (167.0-377.5 min), and sleep efficiency was found to be 61.7% (34.6-71.7%). The percentage for N3 and REM sleep was found to be 15.0% (0-34.6%) and 12.7% (0-22.2%), respectively. Both RBD and PLMS were observed more frequently in patients with LGI1-Ab encephalitis. We identified status dissociatus (SD) in five (23.8%) patients with LGI1-Ab encephalitis and two (40%) patients with Caspr2-Ab diseases. The former is more likely to have simple limb movements rather than complex movements, which mimic the contents of their dreams. Continuous insomnia was more common in patients with Caspr2-Ab diseases than patients with LGI1-Ab encephalitis. Patients reported clinical and PSG improvements following immunotherapy. Conclusion: Sleep disorders in patients with VGKC-Ab-associated diseases include decreased TST and poor sleep efficiency. Our studies provide evidence of SD in patients with LGI1-Ab encephalitis.

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Section: Resultsmentioning

confidence: 99%

Section: Sleep Assessmentsmentioning

confidence: 99%

Section: Sleep Assessmentsmentioning

confidence: 99%

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Sleep Disorders in Leucine-Rich Glioma-Inactivated Protein 1 and Contactin Protein-Like 2 Antibody-Associated Diseases

et al. 2020

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“…These two states are mutually exclusive each other under normal conditions 181,182. But there are situations, such as the state dissociation,183 or deafferentation syndromes, where a set of neurons in the thalamus displays low rhythmicity in an otherwise awake brain state 180…”

Section: Hypothesismentioning

confidence: 99%

Psychosis in parkinsonism: an unorthodox approach

Onofrj

Carrozzino

D’Amico

et al. 2017

NDT

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Psychosis in Parkinson’s disease (PD) is currently considered as the occurrence of hallucinations and delusions. The historical meaning of the term psychosis was, however, broader, encompassing a disorganization of both consciousness and personality, including behavior abnormalities, such as impulsive overactivity and catatonia, in complete definitions by the International Classification of Diseases-10 (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Our review is aimed at reminding that complex psychotic symptoms, including impulsive overactivity and somatoform disorders (the last being a recent controversial entity in PD), were carefully described in postencephalitic parkinsonism (PEP), many decades before dopaminergic treatment era, and are now described in other parkinsonisms than PD. Eminent neuropsychiatrists of the past century speculated that studying psychosis in PEP might highlight its mechanisms in other conditions. Yet, functional assessments were unavailable at the time. Therefore, the second part of our article reviews the studies of neural correlates of psychosis in parkinsonisms, by taking into account both theories on the narrative functions of the default mode network (DMN) and hypotheses on DMN modulation.

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“…Status dissociatus is seen in a variety of conditions including rapidly progressive neurodegenerative disorders (fatal familial insomnia and other prion diseases), autoimmune encephalitis (voltage‐gated potassium channel antibodies and anti‐Ma encephalitis), alcohol or drug abuse (particularly during acute withdrawal states), brain lesions (hypothalamic, thalamic, and brainstem lesions), neurodegenerative diseases (particularly DLB), and rare congenital disorders (Mulvihill‐Smith syndrome) . In patients with N‐methyl‐ d ‐aspartate encephalitis, it has even been hypothesized that the occurrence of orofacial dyskinesias (which may occur exclusively during sleep) may represent status dissociatus …”

Section: Parasomniasmentioning

confidence: 99%

Sleep‐related motor and behavioral disorders: Recent advances and new entities

et al. 2018

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Patients with sleep-related motor and behavioral disorders present to a variety of subspecialty clinics (neurology, sleep medicine, respiratory medicine, psychiatry). Diagnosing these disorders can be difficult, and sometimes they have a significant impact on quality of life. Alongside a number of common and well-recognized conditions, several new disease entities have been described in recent years that present with abnormal nocturnal motor phenomena (such as ADCY5-associated disease and anti-IgLON5 disease). Our understanding of the neural basis and prognostic significance of other sleep-related disorders has also grown, particularly rapid eye movement sleep behavior disorder. This review (along with a collection of previously unpublished videos) is intended to aid in the recognition and treatment of these patients. The recent change in terminology from nocturnal frontal lobe epilepsy to sleep-related hypermotor epilepsy is also discussed. © 2018 International Parkinson and Movement Disorder Society.

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From state dissociation to status dissociatus

Cited by 58 publications

References 91 publications

Sleep Disorders in Leucine-Rich Glioma-Inactivated Protein 1 and Contactin Protein-Like 2 Antibody-Associated Diseases

Sleep Disorders in Leucine-Rich Glioma-Inactivated Protein 1 and Contactin Protein-Like 2 Antibody-Associated Diseases

Psychosis in parkinsonism: an unorthodox approach

Sleep‐related motor and behavioral disorders: Recent advances and new entities

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