In Ghana, migration has traditionally been dominated by males leaving women and children behind until thelate 1980s when females begun to migrate independently. Consequently, there is paucity of literature on theexperiences of left-behind husbands whose wives had migrated internally. Using the Nandom Municipality as acase study, 331 left-behind husbands responded to a survey questionnaire while 15 others participated in indepthinterviews. The quantitative data were analyzed using both descriptive statistics and a binary logisticregression while content analysis based on common themes was employed to analyze the qualitative data thatwere transcribed. The study shows that the left-behind husbands, who were mostly subsistence farmers withprimary or no formal education, approved their wives’ decision to migrate based on economic reasons. In theabsence of their wives, most men experienced challenges in cooking, drawing water, cleaning the home,shopping, sowing/planting, weeding, harvesting and carting of farm produce home or to the market for sale. Inparticular, husbands who were older, had secondary education or had younger children experienced morechallenges in the absence of their wives. As a coping strategy, most of the left-behind husbands relied on supportfrom the extended family members in both household chores and some farming activities. From the findings,there is the need to provide children of both sexes with the same socialization process to curb gender division oflabour in the Nandom Municipality. It is also important to promote female education and skilled training toreduce out-migration of females from the Nandom Municipality.