From targeted methods to metabolomics based strategies to screen for growth promoters misuse in horseracing and livestock: A review

Cloteau, Chloé; Kaabia, Zied; Bizec, Bruno Le; Bailly-Chouriberry, Ludovic

doi:10.1016/j.foodcont.2023.109601

Food Control

2023

DOI: 10.1016/j.foodcont.2023.109601

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From targeted methods to metabolomics based strategies to screen for growth promoters misuse in horseracing and livestock: A review

Chloé Cloteau

Zied Kaabia²,

Bruno Le Bizec

et al.

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Cited by 5 publications

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Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry

Mosburg,

Li,

Helmes

et al. 2024

Drug Testing and Analysis

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Hormonal growth promotants (HGPs) are a class of pharmaceutical agents commonly administered to cattle in the United States to improve growth rates of the animal, alter behavior, or to improve the desired characteristics of retail cuts of meat. There is a concern that low residual concentrations of HGPs may remain in tissue after slaughter, and consumption of tissues containing these compounds may increase the risk of adverse health outcomes, including cancer. Sensitive and selective methods are necessary to assess exposure of HGPs by populations that consume meat products from animals that may have been administered HGPs. A liquid chromatography–tandem mass spectrometry method was developed and validated to detect the low‐level presence of HGPs including estradiol, testosterone, estradiol benzoate, melengestrol, melengestrol acetate, progesterone, testosterone propionate, trenbolone, trenbolone acetate, and α‐zearalanol in retail cuts of meat following a liquid–liquid extraction using a high pH solution with 30–50× less mass of meat required as compared to similar approaches. Good chromatographic performance and sensitivity was achieved utilizing ammonium fluoride as a mobile phase additive without the need for derivatization. Validation parameters including accuracy, precision, recovery, matrix effects, limits of detection, limits of quantitation, linear range, and stability were determined. The limits of detection ranged from 0.1 to 1.0 ng/g, depending on the compound, with adequate accuracy and precision without the need for extensive sample preparation approaches.

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Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry

Mosburg,

Li,

Helmes

et al. 2024

Drug Testing and Analysis

View full text Add to dashboard Cite

show abstract

On-site monitoring of nandrolone in cattle farming samples by portable atmospheric pressure chemical ionization mass spectrometry with ambient sampling

Wu,

Wang,

Tang

et al. 2024

Journal of Chromatography B

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Anabolic steroids in livestock production: Background and implications for chemical food safety

Chen,

Le Bizec,

Dervilly

2024

Steroids

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From targeted methods to metabolomics based strategies to screen for growth promoters misuse in horseracing and livestock: A review

Cited by 5 publications

References 185 publications

Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry

Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry

On-site monitoring of nandrolone in cattle farming samples by portable atmospheric pressure chemical ionization mass spectrometry with ambient sampling

Anabolic steroids in livestock production: Background and implications for chemical food safety

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