From tea to treatment; epigallocatechin gallate and its potential involvement in minimizing the metabolic changes in cancer

Abstract

This study utilized a series of medical databases, inclusive of PubMed, EMBASE, MedLine, and SciFinder for articles published in the past 20 years to obtain a viable and comprehensive depiction of our current understanding of EGCG and its potential involvement in minimizing the deregulated of biochemical pathways observed in cancers. Search strategies began with using keywords such as "epigallocatechin gallate" AND "prostate cancer", or more generally "green tea" AND "metastasis". As data were collected and the interacting pathways better comprehended, the search requests expanded to more expansively investigate the involved PI3K/Akt/mTOR pathway, history, and previous association of green tea as a chemopreventive medicine, and studies investigating the modern approach to targeting the metabolic pathways of cancer. 3. Green Tea. Source and Bioactivity. 3.1 Botanical Source EGCG is most abundantly found in green tea; however, it is also present in black and oolong teas, along with trace amounts found in miscellaneous fruit and vegetables [15]. All three of the major tea varieties including black, oolong, and green, are sourced from the Camellia sinensis plant, which grows globally in warm and humid climates [16]. China, Indonesia, Sri Lanka, and southern India have a year-round harvesting and growing season, whereas areas such as northern-eastern

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

“…Epigallocatechin has been widely described as an epigenetic modulator and is a component of some MD fruits, such as as cranberries and pomegranates [86,87]; it has been even proposed as an epigenetic adjuvant in Down Syndrome management to balance the abnormal DNA methlyation caused by the overdose of chromosome 21 genes [88]. Epigallocatechin is also able to regulate the expression of some important genes, among which are those encoding phase II antioxidant enzymes, DNA methyltransferases, and histone acetyl transferases: all these genes are capable of triggering/mediating numerous crucial epigenetic mechanisms in cells [89].…”

Epigallocatechin-3-Gallate Suppresses the Expression of TNF-α-Induced MMP-1 <i>via</i> MAPK/ERK Signaling Pathways in Human Dermal Fibroblasts

“…Many substances have demonstrated suppressed skin aging through this models. [6][7][8] Epigallocatechin-3-gallate (EGCG, Fig. 1A) is an important component of polyphenol in green tea, and it is well known for its anti-cancer, antiinflammatory, and antioxidant effects.…”

“…1A) is an important component of polyphenol in green tea, and it is well known for its anti-cancer, antiinflammatory, and antioxidant effects. 9,10) In skins, EGCG has been reported for its antiaging effects by suppressing MMP increase induced by fine dust, heat shock, and UVB. [11][12][13] However, there have been no reports of MMP-1 suppression in dermal fibroblasts stimulated by TNF-α.…”

EGCG Mediated Targeting of Deregulated Signaling Pathways and Non-Coding RNAs in Different Cancers: Focus on JAK/STAT, Wnt/β-Catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL Mediated Signaling Pathways

“…Epigallocatechin-3-gallate (EGCG) is a phenolic compound present in tea and has captivated tremendous attention in the past two decades because of its premium pharmacological properties. There is a wide variety of reviews published with reference to EGCG mediated anticancer effects [1][2][3][4]. However, in this review we focused on EGCG mediated modulation of deregulation cell signaling pathways in different cancers.…”