This chapter recounts the twilight of alchemy and the rise of modern chemistry. Both play a major role in the expansion of the artists' palette during the 17th, 18th and first half of the 19th centuries. Though the alchemy was accidental, the modern chemists had their share of accidents as well. But careful analytical chemists, well-schooled in the thought processes of Antoine-Laurent Lavoisier, the father of modern chemistry, were the stars of the show: together, they contributed dozens of new pigments to the artists' palette.