From the Archives of the AFIP

Woodward, Paula J.; Sohaey, Roya; O’Donoghue, Michael; Green, Douglas E.

doi:10.1148/radiographics.22.1.g02ja14189

Cited by 296 publications

(57 citation statements)

References 70 publications

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“…The use of scrotal US has resulted in an increase in incidentally detected non‐palpable testicular lesions, with a sensitivity ranging between 90 and 100% (Woodward et al ., 2002; Appelbaum et al ., 2013). However, US differentiation between benign and malignant testicular neoplasms and, occasionally, between neoplastic and non‐neoplastic incidental lesions is limited (Lotti & Maggi, 2015).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of qualitative and strain ratio elastography in the differential diagnosis of non‐palpable testicular lesions

et al. 2016

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SummaryThe purpose of this study was to evaluate prospectively the accuracy of qualitative and strain ratio elastography (SE) in the differential diagnosis of non‐palpable testicular lesions. The local review board approved the protocol and all patients gave their consent. One hundred and six patients with non‐palpable testicular lesions were consecutively enrolled. Baseline ultrasonography (US) and SE were correlated with clinical and histological features and ROC curves developed for diagnostic accuracy. The non‐palpable lesions were all ≤1.5 cm; 37/106 (34.9%) were malignant, 38 (35.9%) were benign, and 31 (29.2%) were non‐neoplastic. Independent risk factors for malignancy were as follows: size (OR 17.788; p = 0.002), microlithiasis (OR 17.673, p < 0.001), intralesional vascularization (OR 9.207, p = 0.006), and hypoechogenicity (OR, 11.509, p = 0.036). Baseline US had 89.2% sensitivity (95% CI 74.6–97.0) and 85.5% specificity (95% CI 75.0–92.8) in identifying malignancies, and 94.6% sensitivity (95% CI 86.9–98.5) and 87.1% specificity (95% CI 70.2–96.4) in discriminating neoplasms from non‐neoplastic lesions. An elasticity score (ES) of 3 out of 3 (ES3, maximum hardness) was recorded in 30/37 (81.1%) malignant lesions (p < 0.001). An intermediate score of 2 (ES2) was recorded in 19/38 (36.8%) benign neoplastic lesions and in 22/31 (71%) non‐neoplastic lesions (p = 0.005 and p = 0.001 vs. malignancies). None of the non‐neoplastic lesions scored ES3. Logistic regression analysis revealed a significant association between ES3 and malignancy (χ2 = 42.212, p < 0.001). ES1 and ES2 were predictors of benignity (p < 0.01). Overall, SE was 81.8% sensitive (95% CI 64.8–92.0) and 79.1% specific (95% CI 68.3–88.4) in identifying malignancies, and 58.6% sensitive (95% CI 46.7–69.9) and 100% specific (95% CI 88.8–100) in discriminating non‐neoplastic lesions. Strain ratio measurement did not improve the accuracy of qualitative elastography. Strain ratio measurement offers no improvement over elastographic qualitative assessment of testicular lesions; testicular SE may support conventional US in identifying non‐neoplastic lesions when findings are controversial, but its added value in clinical practice remains to be proven.

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Section: Introductionmentioning

confidence: 99%

Diagnostic value of qualitative and strain ratio elastography in the differential diagnosis of non‐palpable testicular lesions

et al. 2016

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“…7 Menon and colleagues reported immunoreactivity to pancytokeratin, cytokeratin 20 and CEA in a case of primary borderline mucinous testicular cystadenoma. 8 Sonographic appearance of these tumours is often nonspecific and similar to those of other malignant tumours, such as teratomas. 9 Peripheral or paratesticular localization, especially with the tunica vaginalis or tunica albuginea, often correlates with adenofibromas and other types of ovarian-type epithelial and stromal tumours.…”

Section: Discussionmentioning

confidence: 99%

Primary testicular mucinous cystadenoma: Case report and literature review

Lima¹,

Granja

2015

CUAJ

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Testicular mucinous cystadenomas are rare in urological practice, and their histogenesis, course and management are debated. We report a primary testicular mucinous cystadenoma in a 54-year old male who presented with left testicular swelling and pain. He denied having a history of cryptorchidism, testicular trauma, infections, urinary complaints, or febrile illnesses. He did not have diabetes, but was on treatment for hypertension. The patient underwent a left inguinal radical orchiectomy, and histological examination of the resected tumour confirmed a primary testicular mucinous cystadenoma. The patient had an uneventful recovery, and is being followed up. Conclusively, urologists need to maintain a high index of suspicion of these tumours and their differentiation from metastatic tumours to ensure optimal therapeutic outcomes.

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“…It accounts for 35%-50% of all germ cell tumors (Woodward et al, 2002). Seminomas occur in a slightly older age group when compared with other nonseminomatous tumor, with a peak incidence in the forth and fifth decades.…”

Section: Seminomamentioning

confidence: 99%

“…4]. Yolk sac tumor ---Yolk sac tumors also known as endodermal sinus tumors account for 80% of childhood testicular tumors, with most cases occuring before the age of 2 years (Woodward et al, 2002, as cited in Frush & Sheldon 1998. Alpha-fetoprotein is normally elevated in greater than 90% of patients with yolk sac tumor (Woodward et al, 2002, as cited in Ulbright et al, 1999.…”

Section: Nonseminomatous Germ Cell Tumorsmentioning

confidence: 99%