From the Archives of the AFIP

Abbott, Robert M.; Levy, Angela D.; Aguilera, Nadine S.; Gorospe, Luis; Thompson, William M.

doi:10.1148/rg.244045006

Cited by 332 publications

(152 citation statements)

References 79 publications

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“…46 On ultrasonography, splenic hamartomas are typically solid homogeneous masses, hypoechoic relative to the normal adjacent splenic parenchyma. At colour Doppler, these lesions often demonstrate increased blood flow.…”

Section: Biliary Hamartomasmentioning

confidence: 99%

“…At colour Doppler, these lesions often demonstrate increased blood flow. 46 At CT, hamartomas can be difficult to detect, as they are usually isointense to normal splenic tissues on non-contrast and contrast-enhanced images. Sometimes, the only finding is a contour abnormality.…”

Section: Biliary Hamartomasmentioning

confidence: 99%

“…Sometimes, the only finding is a contour abnormality. 46 At MRI, splenic hamartomas are well defined with smooth borders, clearly separated from normal splenic tissues. They are typically isointense relative to normal splenic parenchyma on T 1 weighted images, heterogeneously hyperintense on T 2 weighted images and show heterogeneous enhancement on early post-contrast T 1 weighted images.…”

Section: Biliary Hamartomasmentioning

confidence: 99%

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Hamartomas from head to toe: an imaging overview

Herrán

Restrepo

Gomez

et al. 2017

The British Journal of Radiology

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Hamartomas are tumours composed of mesenchymal tissues such as cartilage, fat, connective tissue and smooth muscle and can be found in virtually any organ system. These masses commonly develop sporadically, but are also seen in certain syndromes such as tuberous sclerosis or Carney triad. While their imaging appearance varies depending on the organ they arise from, findings are usually unique and a diagnosis can be confidently made. Radiologists must be aware of the clinical and imaging presentations of these lesions with the particular goal of avoiding unnecessary studies or invasive procedures. Furthermore, knowledge of common syndromic entities is crucial, as the radiologist may be the first to suggest the diagnosis.

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Section: Biliary Hamartomasmentioning

confidence: 99%

Section: Biliary Hamartomasmentioning

confidence: 99%

Section: Biliary Hamartomasmentioning

confidence: 99%

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Hamartomas from head to toe: an imaging overview

Herrán

Restrepo

Gomez

et al. 2017

The British Journal of Radiology

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“…These tumors do not show the capsular-like rim because their growth is very slow, so the peritumoral fibrous capsule rarely occurs. 19 Therefore, the combination of delayed enhancement and a capsular-like rim may be imaging findings that help us differentiate IPT-like FDCTs from other splenic tumors.…”

Section: Only 19 Cases Of Splenic Ipt-like Fdcts or Iptsmentioning

confidence: 99%

Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor of the Spleen: Case Report and Review of the Literature

Kitamura

Takayama

Nishie

et al. 2015

MRMS

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A 74-year-old woman underwent contrast-enhanced (CE) computed tomography (CT) that revealed an enlarging splenic lesion. This splenic tumor was suspected as metastasis because the patient had been diagnosed with right breast cancer with lung and right axillary lymph node metastases 4 years earlier and had undergone surgery and hormone therapy at another hospital. T 2 -weighted imaging of magnetic resonance (MR) imaging demonstrated the tumor with slightly high intensity with a rim of low intensity at the margin. On dynamic contrast-enhanced (DCE)-MR imaging after intravenous administration of gadolinium diethylenetriamine pentaacetic acid, delayed enhancement was observed in the center and margin of the tumor. On positron emission tomography with 2-deoxy-2-[18F] fluoro-Dglucose (FDG) integrated with CT, the tumor showed high FDG uptake. Splenic metastasis was considered based on the imaging findings, lack of inflammation on laboratory data, and clinical course, so she underwent splenectomy. Histopathologically, the tumor was encapsulated by a fibrous structure, which was depicted as the rim at the tumor margin on T 2 -weighted imaging and DCE-MR imaging. Immunohistochemical study allowed the diagnosis of inflammatory pseudotumor (IPT)-like follicular dendritic cell tumor (FDCT). FDCT is a primary neoplasm of lymph nodes that shows features of follicular dendritic cell differentiation, and it is rare at the spleen. Differential diagnosis is difficult between IPTlike FDCT and similar splenic tumors, such as IPT, splenic metastases, hamartoma and hemangioma. However, in addition to the enhancement pattern within a tumor on DCE-MR imaging, detection of the capsular-like rim on MR imaging might aid the diagnosis of splenic IPT-like FDCT.

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“…Some of these masses has shown the peripheral enhancement, and the margins of the lesions could not see clearly [13,16,17] . On MRI, areas of increased and decreased signal intensity may be seen on images obtained with both T1-and T2-weighted pulse sequences, and contrast-enhanced MRI reveals heterogeneous enhancement within the tumor [18,19] . Low-signal-intensity areas on MRI probably represent siderotic nodules [20] .…”

Section: Discussionmentioning

confidence: 99%

Primary splenic angiosarcoma with liver metastasis: A case report and literature review

Yang¹,

Li²,

Wang³

et al. 2016

WJG

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had the surgery; Yang JW has helped the bibliography search; Yang KF has done the data collection and then finished the report.Supported by The First Affiliated Hospital of Nanchang University, Jiangxi Province, China.Institutional review board statement: The research was verified by the First Affiliated Hospital of Nanchang University Institutional Review Board, Nanchang, China.Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment. Conflict-of-interest statement:The authors announced that there is no conflict of interest exists in manuscript, included personal, political, and others. AbstractPrimary splenic angiosarcoma (PSA) is an unusual and highly malignant vascular tumour with a high rate of metastatic. Moreover, the research on prognosis of the disease is poor. The epidemiology, etiology, clinical diagnosis and treatment of the disease remain challenging, because case reports of the disease are few in number. In accordance with other malignant tumors, PSA is very aggressive, and the majority of patients in which this disease is found are at an advanced stage. Almost all patients die within 12 mo of diagnosis irrespective of treatment. We report here a woman who had complained of upper bellyache and anorexia for 10 d. Magnetic resonance imaging showed enlargement of the spleen with multiple heterogeneous masses in the lower pole of the spleen. A hand-assisted laparoscopic splenectomy was performed which allowed histopathologic diagnosis. The patient was diagnosed with PSA and liver metastasis, and succumbed to the disease 35 d after surgery. The literature was finished combined with the clinical features, diagnosis and management of PSA. Core tip: Primary splenic angiosarcoma (PSA) is an unusual tumor originating from the blood vessel. To date, very few cases of PSA have been reported. We report a woman who had PSA after splenectomy, and liver metastasis was also detected. The patient heterogeneous mass of 7.8 cm × 5.7 cm and multiple nodules in the liver parenchyma (Figure 1). So the diagnosis of the primary splenic malignancy with hepatic metastasis was suggested based on imaging findings. A hand-assisted laparoscopic splenectomy was then performed not only for the purpose of curing the disease, but also for histopathologic diagnosis. In this process, the patient had received 2 units of fresh frozen plasma and frozen plasma, 3 units of blood cells and 6 units of cryoprecipitate. Intraoperatively, we observed a scleroid tumor mass 6 cm × 5 cm in size in the lower pole of the spleen. A cross-section of the specimen demonstrated a wellcircumscribed grayish yellow lesion. In accordance with the imaging findings, laparotomy revealed micrometastases in the liver. Thus, a histopathologic biopsy was carried out. The pathologic diagnosis of the excised spleen was originating from the spleen (Figure 2) and liver metastasis, which were confirmed by pathologic examination of the biopsied specimen. Immunohistochemical analysis showed t...

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From the Archives of the AFIP

Cited by 332 publications

References 79 publications

Hamartomas from head to toe: an imaging overview

Hamartomas from head to toe: an imaging overview

Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor of the Spleen: Case Report and Review of the Literature

Primary splenic angiosarcoma with liver metastasis: A case report and literature review

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