From the Editor

Elevated Frequency of Carriers for Triosephosphate Isomerase Deficiency in Newborn Infants

“…Only a single TPI electrophoretic variant occurring in a White infant, has been observed among 2224 newborns (frequency = 0.004). The average frequency of electrophoretic variants at 29 loci encoding other erythrocyte enzymes is 0.013 in this population (28).…”

“…A significant degree of sequence homology is observed in enzymes from divergent species (2,4,21,38), especially in the active site region (I 8), indicating a slow rate of evolution (9). Few electrophoretic variants have been identified in surveys of human populations (25,28,29).…”

Gene mutations (de novo) found in electrophoretic studies of blood protein of infants with anomalous development.

“…However, recently, within the framework of the SovietAmerican Cooperation Program in the field of environmental protection, scientists from the United States of America (1)(2)(3)(4) and the Union of Soviet Socialist Republics (5)(6)(7)(8) (9) and in man (6) of a coadapted genetic system formed by stabilizing selection within a population and providing maximal fitness of morphologically "average" phenotypes; second, the discovery of system stability in native subdivided populations (10), which qualitatively distinguishes them from populations in which the vectorized genetic process is going on (8); and third, description of the genetic monomorphism phenomenon, which reflects the existence of loci whose mutational disturbances are incompatible with normal ontogenesis (11)(12)(13).…”