From the Gender Gap to Neuroactive Steroids: Exploring Multiple Cases to Further Understand Neuropathic Pain

Marinelli, Sara; Coccurello, Roberto

doi:10.3390/ijms24108577

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Sports medicine specialists can encourage athletes to use analgesics responsibly by maintaining regular contact with them, providing them with continuing support, and stressing the significance of reporting any side effects or concerns right away (Marinelli and Coccurello 2023).…”

Section: Regulatory Compliance and Responsible Use Educationmentioning

confidence: 99%

Tackling pain and inflammation: The impact of analgesics in sports medicine

Sethi,

Talvelkar

2024

Multidiscip. Rev.

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Throughout their careers, athletes frequently struggle with pain and inflammation, which frequently reduces performance and slows recovery. The use of analgesics in sports medicine is examined here, with a focus on how athletes might manage their pain and inflammation. In the opening section of the chapter, a general overview of pain and inflammation in relation to sports injuries is given, emphasizing the negative consequences these conditions have on athletic performance. We explored the numerous analgesics used in sports medicine, such as acetaminophen, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and local anesthetics. The mode of action, indications, advantages, drawbacks, and potential side effects of each analgesic class are examined, highlighting the importance of comprehending how each affects the well-being and performance of athletes. The article also explored the effects of analgesics on athletic performance, outlining both the advantages of temporary pain relief and potential drawbacks such as hiding underlying problems or encouraging dependency. It is highlighted how crucial it is for athletes to have individualized pain management programs, as the fine line between pain management and injury aggravation is discussed. In addition, ethical issues surrounding the use of analgesics in sports, such as doping laws, fair play, and possible analgesic abuse for the purpose of enhancing performance, are discussed. To maintain the integrity of sports and safeguard athletes' wellbeing, the responsible use of and adherence to rules are strongly encouraged. This review examines integrative treatments in sports medicine, such as physical therapy, mind-body interventions, and nutritional interventions, which provide effective alternatives for managing pain and inflammation without relying primarily on analgesics in light of alternative approaches. Examples of analgesic use in sports medicine are highlighted in real-world case studies, highlighting how it affects players' careers and well-being. The review's conclusion looks at potential long-term consequences for athletes' health as well as future directions.

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Section: Regulatory Compliance and Responsible Use Educationmentioning

confidence: 99%

Tackling pain and inflammation: The impact of analgesics in sports medicine

Sethi,

Talvelkar

2024

Multidiscip. Rev.

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“…For instance, eligible AD patients could be recruited in specific exercisefocused rehabilitation programs with the parallel quantification of irisin blood levels and GM analysis longitudinally at different time points. Meanwhile, the same AD patients could be screened for the expression of NPSs and the use/prescription of antipsychotic medications, with a focus on gender-specific differences that, compared with other fields of medicine [244][245][246], are currently often neglected.…”

Section: Conclusion and Limitationsmentioning

confidence: 99%

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

Cutuli,

Decandia,

Giacovazzo

et al. 2023

IJMS

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Alzheimer’s disease (AD) is a common cause of dementia characterized by neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms. Physical exercise (PE) has emerged as a powerful tool for reducing chronic inflammation, improving overall health, and preventing cognitive decline. The connection between the immune system, gut microbiota (GM), and neuroinflammation highlights the role of the gut–brain axis in maintaining brain health and preventing neurodegenerative diseases. Neglected so far, PE has beneficial effects on microbial composition and diversity, thus providing the potential to alleviate neurological symptoms. There is bidirectional communication between the gut and muscle, with GM diversity modulation and short-chain fatty acid (SCFA) production affecting muscle metabolism and preservation, and muscle activity/exercise in turn inducing significant changes in GM composition, functionality, diversity, and SCFA production. This gut–muscle and muscle–gut interplay can then modulate cognition. For instance, irisin, an exercise-induced myokine, promotes neuroplasticity and cognitive function through BDNF signaling. Irisin and muscle-generated BDNF may mediate the positive effects of physical activity against some aspects of AD pathophysiology through the interaction of exercise with the gut microbial ecosystem, neural plasticity, anti-inflammatory signaling pathways, and neurogenesis. Understanding gut–muscle–brain interconnections hold promise for developing strategies to promote brain health, fight age-associated cognitive decline, and improve muscle health and longevity.

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From the Gender Gap to Neuroactive Steroids: Exploring Multiple Cases to Further Understand Neuropathic Pain

Abstract: Neuropathic pain (NeuP) is still an intractable form of highly debilitating chronic pain, resulting from a lesion or disease of the somatosensory nervous system [...]

Cited by 2 publications

References 18 publications

Tackling pain and inflammation: The impact of analgesics in sports medicine

Tackling pain and inflammation: The impact of analgesics in sports medicine

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

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