From the hive: Honey, a novel weapon against cancer

Badolato, Mariateresa; Carullo, Gabriele; Cione, Erika; Aiello, Francesca; Caroleo, Maria Cristina

doi:10.1016/j.ejmech.2017.07.064

Cited by 78 publications

(73 citation statements)

References 88 publications

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“…Although the plant kingdom constitutes an extraordinary reservoir of novel bioactive organic molecules, this resource was not fully appreciated until the recent worldwide surge of interest in herbal medicine [24]. Medicinal plants can biosynthesize chemical compounds with different biological properties [25], and these have long been used for treating various civilization diseases including cancer [26][27][28][29]. Cancer is an established global health problem known to account for nine million deaths globally, and is expected to increase to about 15 million by 2030 [27].…”

Section: Discussionmentioning

confidence: 99%

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

et al. 2020

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Natural compounds isolated from plants are excellent starting points in drug design and have been widely studied as anticancer agents; they hence find use in a considerable proportion of anticancer drugs. The genus Plectranthus (Lamiaceae) comprises a large and widespread group of species with various applications in traditional medicine. Therefore, the aim of the present study was to determine the effectiveness of treatment with four abietane diterpenoids isolated from P. madagascariensis and P. ecklonii, 6,7-dehydroroyleanone, 7β,6β-dihydroxyroyleanone, 7α-acetoxy-6β-hydroxyroyleanone and parvifloron D, in initiating apoptosis in a glioma cell line. The pure compounds were found to exhibit anticancer effects in primary H7PX glioma cells line by inducing apoptosis G2/M cell cycle arrest and double-strand breaks, indicated by increased levels of phosphorylated H2A.X and decreasing mitochondrial membrane potential; they also influenced the expression of pro- and anti-apoptotic genes (Bax, Bcl-2, TP53, or Cas-3). Our findings indicate that these compounds may offer potential as beneficial antitumor drugs but further in vivo studies are needed.

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Section: Discussionmentioning

confidence: 99%

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

et al. 2020

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“…In our experimental set-up, anti-intravasative flavonoids with up to four-fold higher activity than hispidulin (IC 50 : 89 µM) were identified, namely luteolin (IC 50 : 19 µM) as the most potent one > chrysin (IC 50 : 25 µM) > apigenin (IC 50 : 34 µM) > acacetin (IC 50 : 37 µM) > galangin (IC 50 : 40 µM) > kaempferol (IC50: 45 µM) (see Table 1). The tested flavonoids are present in fruits and vegetables, plants, mushrooms, bee pollen and propolis [21,22]. Yet, the bio-available concentrations are too low to achieve LEC barrier stabilization by dietary consumption [23].…”

Section: Discussionmentioning

confidence: 99%

Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids

et al. 2019

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We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the circular chemorepellent-induced defects (CCID)-assay. Bay11-7082, a known inhibitor of CCID formation served as the positive control. This study provides the first comparison of the potential of flavonoids to suppress features influencing the intravasation of MCF-7 breast cancer cells aggregates through the lymph endothelial barrier. The most significant effects were seen after incubation with the flavones luteolin, chrysin, and apigenin. Additional hydroxylation or methoxylation in positions 6 or 8, as expected, resulted in decreased activity. The tested flavanones remained without or low efficacy.

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“…4,[42][43][44] NHO with various antioxidant compounds, especially phenolic compounds, is one of the most nutritious foods, which its effects on many disorders and diseases have been discussed with particular attention in many studies. 17,[45][46][47][48] Thus, the present study was designed to confirm the beneficial effects of the chronic administration of NHO in combination with morphine in modulating the dependence and withdrawal symptoms of opioids, as well as determining the role of antioxidant compounds in NHO in preventing the development of oxidative stress and its effects on the long term use of morphine. The results showed that the chronic administration of NHO could attenuate morphine dependence and serum level of TNF-α, however further studies are needed to achieve complete evidence and to find the exact mechanisms of action regarding the main components of NHO influencing morphine dependence.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effects of Chronic Administration of Natural Honey on the Development of Dependence on Morphine in the Male Rats

2019

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Background: According to the previous studies, the exact mechanism of dependence on opioids and withdrawal syndrome has not been fully understood but one of the most important mechanisms is the increase of pro-inflammatory cytokines in CNS. On the other way, previous studies showed that natural honey (NHO) has anti-inflammatory properties. This study was aimed to evaluate the effects of chronic administration of natural honey on the development of morphine dependence in male rats. Methods: Honey was prepared from Tarom Oliya region in Zanjan province. Experiments were performed on male Wistar rats weighing 225-275 g, randomly divided into 6 groups (n=8). The study groups included morphine group, the three doses of morphine plus honey group (at doses of 200,400 and 800 mg/kg, i.p.), the morphine plus vehicle group, and the saline group. The subcutaneous injections of additive doses of morphine were used for 9 days to create morphine dependency. On the 9th day, one hour after the morning dose of morphine, naloxone (4 mg/kg, i.p.) was injected, and symptoms of withdrawal syndrome were assessed for 60 minutes. Then, blood samples were taken to measure TNF-α. One-way ANOVA and Tukey tests were used to compare the results. P- Value of <0.05 was considered as statistically significant. Results: The results of this study showed that intraperitoneal injection of honey at 3 doses (200, 400 and 800 mg/kg with p <0.001) could significantly decrease the total score of the symptoms compared to the morphine-vehicle control group. Natural honey (NHO) could significantly decrease TNF-α at dose of 400 mg/kg. Conclusion: The results indicated that chronic administration of NHO had beneficial effects in reducing symptoms of morphine withdrawal syndrome, and this effect is probably due to the anti-inflammatory effect caused by the polyphenolic compounds in honey.<br />

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From the hive: Honey, a novel weapon against cancer

Cited by 78 publications

References 88 publications

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids

Evaluating the Effects of Chronic Administration of Natural Honey on the Development of Dependence on Morphine in the Male Rats

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