From the printer to the lungs: Inkjet-printed aerogel particles for pulmonary delivery

López‐Iglesias, Clara; Casielles, Alba M.; Altay, Ayça; Bettini, Ruggero; Álvarez-Lorenzo, Carmen; García‐González, Carlos A.

doi:10.1016/j.cej.2018.09.159

Cited by 71 publications

(41 citation statements)

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“…Alginate gels in the wet and dry forms are of relevance in several research fields like thermal insulation, wound healing, drug delivery, tissue engineering, absorption or catalysis [19,20,21,22,23]. The study of the physicochemical properties of these alginate-based materials as a function of the processing variables (alginate concentration, gelation conditions, drying method) is of utmost importance.…”

Section: Introductionmentioning

confidence: 99%

Design of Aerogels, Cryogels and Xerogels of Alginate: Effect of Molecular Weight, Gelation Conditions and Drying Method on Particles’ Micromeritics

et al. 2019

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Processing and shaping of dried gels are of interest in several fields like alginate aerogel beads used as highly porous and nanostructured particles in biomedical applications. The physicochemical properties of the alginate source, the solvent used in the gelation solution and the gel drying method are key parameters influencing the characteristics of the resulting dried gels. In this work, dried gel beads in the form of xerogels, cryogels or aerogels were prepared from alginates of different molecular weights (120 and 180 kDa) and concentrations (1.25, 1.50, 2.0 and 2.25% (w/v)) using different gelation conditions (aqueous and ethanolic CaCl2 solutions) and drying methods (supercritical drying, freeze-drying and oven drying) to obtain particles with a broad range of physicochemical and textural properties. The stability of physicochemical properties of alginate aerogels under storage conditions of 25 °C and 65% relative humidity (ICH-climatic zone II) during 1 and 3 months was studied. Results showed significant effects of the studied processing parameters on the resulting alginate dried gel properties. Stability studies showed small variations in aerogels weight and specific surface area after 3 months of storage, especially, in the case of aerogels produced with medium molecular weight alginate.

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Section: Introductionmentioning

confidence: 99%

Design of Aerogels, Cryogels and Xerogels of Alginate: Effect of Molecular Weight, Gelation Conditions and Drying Method on Particles’ Micromeritics

et al. 2019

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“…3D-printed aerogels have been produced for drug delivery applications. For example, thermal inkjet printing (IJP) was used to build alginate aerogel particles impregnated with salbutamol sulfate (SS), a drug used to treat asthma and chronic obstructive pulmonary disease [200]. Thermal IJP is a promising method that allows the processing of printed particles for drug delivery systems with reproducible, narrow particle size distribution and high spatial resolution.…”

Section: Applicationsmentioning

confidence: 99%

“…Scanning electron microscopy (SEM) images of microgel particles printed via IJP of aqueous alginate solutions into baths of CaCl 2 with ( a , c – e ) direct or ( b ) sequential solvent exchange. Reproduced from [200] with permission, copyright Elsevier B.V., 2018.…”

Section: Figurementioning

confidence: 99%

Nanomaterials in Advanced, High-Performance Aerogel Composites: A Review

et al. 2019

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Aerogels are one of the most interesting materials of the 21st century owing to their high porosity, low density, and large available surface area. Historically, aerogels have been used for highly efficient insulation and niche applications, such as interstellar particle capture. Recently, aerogels have made their way into the composite universe. By coupling nanomaterial with a variety of matrix materials, lightweight, high-performance composite aerogels have been developed for applications ranging from lithium-ion batteries to tissue engineering materials. In this paper, the current status of aerogel composites based on nanomaterials is reviewed and their application in environmental remediation, energy storage, controlled drug delivery, tissue engineering, and biosensing are discussed.

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“…[ 5,6 ] Inkjet‐based microsphere production technology offers the potential to improve such limitations to microencapsulation thanks to excellent control and reproducibility of particle size and efficient encapsulation. [ 7,8 ] Furthermore, from the industrial perspective, inkjet‐based technologies represent continuous microdroplet production systems, [ 9,10 ] whereby the process can be fully automated. Importantly, this inkjet set‐up can be easily scaled‐up using multiple printheads working in parallel with hundreds of inkjet ejection nozzles.…”

Section: Figurementioning

confidence: 99%

“…Importantly, this inkjet set‐up can be easily scaled‐up using multiple printheads working in parallel with hundreds of inkjet ejection nozzles. Practical aspects, such as these can provide advantages for microencapsulation in a number of fields and industries: from the pharmaceutical industry [ 7,8 ] to biomedical applications like cell and bacteria microencapsulation. [ 11,12 ]…”

Section: Figurementioning

confidence: 99%

Inkjet‐Based Technology for Microencapsulation of Gold Nanoparticles within Biocompatible Hydrogels

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Ramos‐Sánchez

Serrano‐Sevilla

et al. 2020

Part & Part Syst Charact

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Herein, an inkjet‐based technology as a versatile high throughput methodology for the microencapsulation of gold nanoparticles (AuNPs) inside a biocompatible chitosan hydrogel is described. This continuous automated inkjet production approach generates 30 µm diameter polymeric microcapsules and offers a high rate of production and nanoparticle encapsulation efficiency of 14 nm diameter AuNPs, precise control of the microcapsule size, and ease of scale‐up. The hybrid microcapsules demonstrate biocompatible cell‐adhesion properties and resist degradation over a large range of pH, making them particularly relevant for a variety of potential health applications.

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From the printer to the lungs: Inkjet-printed aerogel particles for pulmonary delivery

Cited by 71 publications

References 50 publications

Design of Aerogels, Cryogels and Xerogels of Alginate: Effect of Molecular Weight, Gelation Conditions and Drying Method on Particles’ Micromeritics

Design of Aerogels, Cryogels and Xerogels of Alginate: Effect of Molecular Weight, Gelation Conditions and Drying Method on Particles’ Micromeritics

Nanomaterials in Advanced, High-Performance Aerogel Composites: A Review

Inkjet‐Based Technology for Microencapsulation of Gold Nanoparticles within Biocompatible Hydrogels

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